🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Big congrats Kelly and George 🤩 looking forward to great science from the Ghanim lab 🤓 mabrouk

Beautiful work congrats to all the team 👏👏

This 👇

Very cool work congrats to both of you 👏👏

We updated our BindCraft preprint with lots of new exciting results! We release all our binder sequences and models, include more in silico analysis, novel design targets, and present AAV retargeting to specific cell types using de novo binders! biorxiv.org/content/10.110…

Finally! Principles for ions binding to RNA, derived from a high resolution structure of the bacterial ribosome, very handy for accurate assignment of ions (and by extension, of water molecules) in ribosome/RNA structures 🤓 academic.oup.com/nar/advance-ar…

We are very excited by this first disclosure of our large collaboration with the lab of Nikhil Munshi Dana-Farber using a cMYC mRNA degrader to affect Multiple Myeloma. ASH Annual Meeting sciencedirect.com/science/articl…

More reversible #RNA modifications 🤩 beyond methylation and dihydrouridine now s4U

Very happy our paper on Zorya anti-phage defense system is now published in nature! 🥳 Big congrats to first authors haidai HU and Philipp Popp and all other authors! Wonderful collab with Marc Erhardt and SimonJackson #cryoEM CPRatUCPH Københavns Uni nature.com/articles/s4158…

Our latest work is out in nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s4158…

The first independent publication from the Berndsen lab Mizzou Biochemistry in collaboration with my colleague C. Keith Cassidy is now peer reviewed and online at nature !! rdcu.be/d3kfg Resolving a many decades-old challenge, we determined the complete structure of

Glad to share our work now published NatureStructMolBiol rdcu.be/d3i8y It took some time but we made it. A detailed intro can be found in below threads which I wrote with passion and hope some time ago. May they stay and thrive. #CryoETforDrugResearch #OpenDataOpenScience

I’m excited to share our latest study led by Giulia Pasquesi out today in Cell Press , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of Jon Markert tinyurl.com/setd2

In our SETD2 paper, we visualize a novel nucleosome transfer intermediate during txn. It is the earliest intermediate visualized yet. In the intermediate, the histone chaperone FACT coordinates histone binding with a previously uncharacterized RTF1 helix: tinyurl.com/setd2

Wow 🤩 amazing work congrats Rachael Kretsch and everyone 👏👏such novelty in RNA structure and unexpected biologically relevant #RNA self-assemblies

New Lab photo

How sturdy are base pairs near the ends of #RNA hairpins? Perhaps not as stable as one might think, esp. when there are bulges near and far. Led by Bou-Nader lab in Nature Communications, we describe complete structures of #HIV #TAR RNA and its dynamic excursions.nature.com/articles/s4146…

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in Science Magazine 🎉 You can find the full story here science.org/doi/10.1126/sc… Verena Resch did a wonderful job on the cover and animation👩‍🎨