Really happy to share this work. EGFR has a ‘magic’ to change cortical actin dynamics without affecting cortical tension. Our further work also follows this point.

E-cadherin-dependent phosphorylation of EGFR governs a homeostatic feedback loop controlling intercellular junction viscosity and ... biorxiv.org/cgi/content/sh… #biorxiv_cellbio

It's a long journey, and the effort has made this true. We discovered a homeostatic feedback loop between E-cadherin and EGFR that regulates intercellular viscosity during collective cell migration. | PNAS pnas.org/doi/10.1073/pn…

Our latest out today nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…

Degrader Tac-opedia 🔘PROTAC: E3 ligase-targeted proteolysis 🔘DUBTAC: Deubiquitinase stabilization 🔘LYTAC: Lysosome-targeted degradation 🔘Trivalent PROTAC: Multivalent E3 ligase 🔘AUTAC: Autophagy-targeted degradation 🔘RIBOTAC: RNA-targeted degradation 🔘RNA-PROTAC: