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Transgenics have the potential to massively expand the power of cell therapies. However, transgenesis adds a step in the already substantial challenge of scaling up cell-based therapies. How do we ensure that cell therapies can harness the power of synthetic biology? 🧵 (1/n)

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

i feel like its so easy to make a good bio podcast 99% of bio podcasts have guests with vaguely interesting backgrounds but are absolutely unwilling to say anything interesting once a mic is put in front of them just like, dont do that its hard to believe that this is

I can't figure out if vaccines work or not. Tough one. I can see why RFK Jr is so concerned. Need Sherlock Holmes on this one.

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

2 important Springer Nature papers on the structure of the dystrophin-glycoprotein (DGC) complex: tinyurl.com/29rnn6ua and tinyurl.com/2vmztm72

Now online! Synthetic organizer cells guide development via spatial and biochemical instructions dlvr.it/TGv5Jv

🚨NEW PUBLICATION ALERT🚨: In a paper out today in Science Magazine we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/sc…. 🧵1/n

My lab's work using genome editing to correct alpha-thalassemia was just published in Cell Reports. Great collaborative work w/ Matt Porteus Stanford Pediatrics, Vivien Sheehan Emory School of Medicine, & Tippi MacKenzie UCSF Surgery: sciencedirect.com/science/articl…

What amount of eye disease research would have discovered the laser? How much virology would have discovered lipid nanobody mRNA delivery? How many disease genes would you need to find before you discovered CRISPR? Sometimes the hardest problems need discoveries in other fields

Physically doing science, not just being talked down to about it, would change a lot of people's minds. Part of the reason why folks are skeptical of scientific institutions is the moat between general public participation and the various fields of research.

Funding from the NIH contributed to the development of 354 out of 356 (99.4%) of the new drugs approved by the FDA between 2010 and 2019, and 🚨 100% 🚨 of FDA approved drugs btw 2010-2016. NIH funding is the backbone of American biomedical innovation. #protecttheNIH

Survival rates for childhood leukaemia over the last decades Staggering progress Science did this Not wellness. Not functional medicine. Not neutraceuticals. Not ivermectin. Science.

I just can't stay silent. Peter Marks stands out as a leader whose career is fundamentally defined by a deep commitment to scientific integrity and principled action. Within his crucial role, particularly at the FDA, he has been instrumental in safeguarding the rigorous

Difficult to overstate how remarkable the Wilkinson opinion is. For seasoned readers of these opinions, the tone and substance are unmistakably unique and severe. This was not a normal opinion for Wilkinson. He knew and clearly hoped the entire country would read this—and I think

Meet 2025 #HertzFellow Chance Bowman, PhD student in 🧬bioengineering at UC San Francisco and UC Berkeley! 🎓 His research investigates how biological systems self-organize—insights that could lead to next-gen cell therapies. 🔗bit.ly/4m2wmbB #Bioengineering #CellTherapy

My new company will market synthetic burgers obtained via Cantor diagonalization over the space of possible genotypes.

My heart goes out to all the families and individuals anxious over their futures following the abrupt and chaotic announcement of H-1B visa changes. America should be working to attract more skilled talent, not create uncertainly that turns them away. To all legal immigrants

Excited to share my project w/Srinivas Viswanathan on virtual CRISPR screening -- predicting cancer dependencies from RNA sequencing alone. On unseen rare tumors, nearly every predicted dependency validated experimentally! Creating a framework to rapidly go from patient → treatment