Thank you for being an incredible audience and for being #CardioNerds ! @Dhruv_mkrishnan signing off for #CardsJC CardioNerds Journal Club. See you next time!

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Thank you to our incredible CardioNerds team and academy fellows! shout out to #HouseTaussig Emily Lee Ramy Doss Maryam Barkhordarian @Dhruv_mkrishnan Adriana C. Mares Chelsea Amo Tweneboah, MD and chief Rawan Amir #CardsJC cardionerds.com/academy/

Thanks for all the help from our incredible panel of experts #CardsJC

Thank you all for your participation on this CardioNerds Journal Club! We truly enjoyed your insight! #CardsJC

❓Any final thoughts about the trial? #CardsJC

What does the world of APT monotherapy vs DAPT hold next?

What trial would you like to see in the headlines?

#CardsJC

Will the results of ULTIMATE-DAPT trial impact your clinical practice?

Will you consider early de-escalation of DAPT in your patients?

#CardsJC

Are the benefits of single therapy with Ticagrelor in patients with ACS observed in this trial believable? #CardsJC

With previous trials such as SMART-DATE & STOPDAPT-2 STEMI suggesting potential harm with shorter DAPT in STEMI, & with the current population consistent of only 30% STEMI, how do you feel about extrapolation of this data to your STEMI population?

#CardsJC

How do you think the lack of availability of high-sensitivity troponin in China & Pakistan impacted the results of this study?

#CardsJC

How do you think the inclusion of non-major (BARC 2) bleeding in primary outcome impacted results?

#CardsJC

And just as a quick reminder! Here is a great infographic reviewing BARC score for bleeding 🩸 by Kate Alta 👩🏼‍🦰

Do you think these outcomes would be reproducible with other, potentially less potent, antiplatelet agents such as Clopidogrel? 💊

#CardsJC

To the Results!🔥

Significantly lower risk of bleeding without increased MACE was observed in ticagrelor monotherapy group compared to DAPT group

Do these results surprise you?

#CardsJC

With 88% of enrolled patient being from China, with known differences in comorbid risk factors between races, are you concerned about the generalizability of these results?

#CardsJC

Now let's take a peek at some baseline characteristics

Any thoughts specifically looking at:

👩 25% female representation?

🫀 NSTEMI/UA to STEMI ratio?

🫀 70% with single vessel disease?

#CardsJC

To the Trial!

Let us look at our inclusion criteria

Does anything catch your eye? 👀

#CardsJC

ULTIMATE-DAPT set out to assess if ticagrelor alone vs ticagrelor & aspirin could ⬇️ major bleeding🩸risk without ⬆️ risk of MACE 🫀

Which will win the ultimate battle? 🥊😉

#CardsJC

To date, there have been many studies in patients post PCI, arguing the utilization and duration of DAPT vs single antiplatelet agent

Here is a quick review 👇

#CardsJC