🥕Devesh Rai, MD🥕 Worldwide 👩‍🦰are about 25-30% of #STEMIs and 30-40% of #ACS cases so at least that? Great question and we have to continue to work to enroll women in trials. We know women are LESS LIKELY to enroll historically. #CardsJC CardioNerds Journal Club

Any thoughts about the implications of the signal suggesting an excess of coronary events in the aspirin-free group? ❤️‍🩹 #CardsJC

CardioNerds Journal Club This finding provides support for use of aspirin (as part of dual antiplatelet therapy) in the earliest periods post PCI. Given findings from other studies evaluating early transition from dual to antiplatelet monotherapy, aspirin (up to 1 month) is beneficial.

How do you think the difference on prasugrel reduced doses 📉 protocol approved only in Japan impacted the results of this study? #CardsJC

A7. Aspirin is still hard to beat! When used in appropriate dosing (low) and in the right clinical context (short-term, post-PCI, post-ACS) #CardsJC @cardionerds @cardionerdsjc

Alison L. Bailey, MD CardioNerds CardioNerds Journal Club I agree. The Prasugrel dosing is low and isn't used in the US. In addition, most bleeding was access site bleeding which probably has more to do with the periprocedural antiplatelet and anticoagulant meds than the subacute oral meds. Limiting IIBIIIA, high radial access= ↘️🩸

🥕Devesh Rai, MD🥕 CardioNerds CardioNerds Journal Club I'm certain. I was not familiar with this dose of prasugrel until reading this trial. 3.75 mg seems << than 10 mg though? I'd be interested in hearing Craig Beavers, PharmD, FACC, FAHA, FCCP, BCCP,CACP and Eugene Yang thoughts here. #CardsJC CardioNerds Journal Club

Is the non-inferiority in CV events and lack of superiority in bleeding risk, comparing aspirin-free therapy vs DAPT one month after PCI, believable? #CardsJC

A8. I'm certain. I was not familiar with this dose of prasugrel until reading this trial. 3.75 mg seems << than 10 mg that is the standard dose. I'd be interested in hearing Craig Beavers, PharmD, FACC, FAHA, FCCP, BCCP,CACP and Eugene Yang thoughts here. #CardsJC CardioNerds Journal Club

CardioNerds Journal Club I don't believe that the findings from this study provide support to omit aspirin immediately post PCI. Fortunately, other studies evaluating this (e.g., LEGACY trial [clinicaltrials.gov/study/NCT05125…]) will help to provide greater insight on this topic.

Clinically, this is relevant since no aspirin might not be the answer for fewer bleeding events. Moreover, there could be a signal for higher coronary events (a 3-fold higher rate of stent thrombosis).

Will the results of the STOPDAPT-3 trial impact your clinical practice? 💡 #CardsJC

I was impressed with 93% rate of intravascular imaging. Maybe with excellent stent deployment aspirin is all that is needed? And low-dose prasugrel didn't add anything? Curious to see what super ⭐️think Dr. Deepak L. Bhatt Hany Ragy MIЯVΛƬ #IC Dr Roxana Mehran #CardsJC CardioNerds Journal Club

Takeaway: STOPDAPT-3 challenges the status quo to tailored antiplatelet therapy post-stenting, especially in the high bleeding risk population. What trial would you like to see in the headlines? #CardsJC

Thank you to our incredible 🤩CardioNerds team and academy fellows! Shout out to Elizabeth Davis,MD, Yeo Yong Hao, Mariana Garcia-Arango, Jake Roberts, MD, Claire Cambron

Stay tuned for more updates and deep dives into the latest cardiology trials. Thanks for joining and sharing your insight! 🫀🩺 CardioNerds Journal Club #CardsJC

Thanks for all the help from our incredible panel of experts #CardsJC

Have you adjusted your DAPT strategy post-PCI based on any recent trials? Share your experiences and thoughts! 💬❤️👇 #InterventionalCardiology #CardsJC

🖊Sign up for our newsletter to find dates and topics for future CardioNerds Journal Club - cardionerds.us4.list-manage.com/subscribe?u=8a…

CardioNerds Journal Club Another practical consideration long term: most of our surgical colleagues are comfortable operating on aspirin. How do they feel operating on SAPT? Will we have to switch SAPT to aspirin then back to SAPT? Look forward to seeing how the science continues to advance. #CardsJC