Delighted to share this research in Current Biology! My thanks to Felix Randow, Wanda Kukulski, Keith Boyle and Sean Munro @CellBiol_MRCLMB. Transbilayer Movement of Sphingomyelin Precedes Catastrophic Breakage of Enterobacteria-Containing Vacuoles cell.com/current-biolog…

Cara Ellison Current Biology Wanda Kukulski @CellBiol_MRCLMB Look who made it onto Twitter. And with a splash! Welcome, Cara.

Cara Ellison Current Biology Felix Randow Wanda Kukulski @CellBiol_MRCLMB Congratulations, Cara (and team)!

Cara Ellison Current Biology Felix Randow Wanda Kukulski @CellBiol_MRCLMB Well done Cara!! Great to see you on twitter 😊

So excited to share latest work from Elliott Lab! We find BIRC6, an enormous #ubiquitin IAP ligase, directly inhibits caspases and we show how this is blocked by SMAC. biorxiv.org/content/10.110… Plus great mass spec collab with Adán Pinto Fernández Kessler Group Oxford

Excited to share our most recent work on the giant ubiquitin ligase #BIRC6 out now in Science Magazine science.org/doi/10.1126/sc…!   Thread below 🧵 (1/7)

What a friendly giant! Enormous ubiquitin ligase BIRC6 protects cells by inhibiting cell death enzymes. SMAC blocks BIRC6, driving timely cell death - So excited to share our work! Science Magazine Elliott Lab Larissa Di Department of Biochemistry at Oxford University Linacre College science.org/doi/10.1126/sc…

#TECPR1 replaces #ATG16 as receptor of the ATG5/ATG12 E3 ligase to conjugate #LC3 to damaged vesicles displaying sphingomyelin on their cytosolic face. New LC3 ligase for #autophagy and first ever receptor for sphingomyelin! Discovered by K.Boyle... embopress.org/doi/full/10.15…