Scientists say they have identified a root cause of lupus — one that could pave the way for new treatments nbcnews.com/health/health-…

In a fun collaboration with Deepak Rao, my superstar PhD student Calvin Law (with Vanessa and Cyan from the Rao lab) discovered mechanisms underlying CXCL13 production specifically and more broadly B-helper T cell differentiation in lupus. nature.com/articles/s4158…

Investigators at Northwestern Medicine and Brigham and Women's Hospital have discovered a molecular defect that promotes the pathologic immune response in #lupus. spr.ly/60199aavh

Thank you! Excited to do what we can to aid in the fight against lupus.

CXCL13 shows up prominently in T cells in autoimmune tissues and tumors. Human Tfh and Tph cells produce lots of CXCL13, yet its regulation is pretty unclear. With beautiful CRISPR screens by Jaehyuk Choi, Calvin Law, we found a few key factors... nature.com/articles/s4158…

In a fun collaboration with Deepak Rao , we tried to decipher the circuitry underlying CXCL13 expression. Chemokine that is prominently expressed by B-helper T cells, exhausted CD8+ T cells, and exhausted PD1-high CD4+ T cell lymphomas.

Very happy to share our latest paper – terrific work by Milad Alasady in PNASNews An HSF1–JMJD6–HSP feedback circuit promotes cell adaptation to proteotoxic stress | PNAS pnas.org/doi/10.1073/pn…

Thanks for all of the support from Shilatifard Lab and the Northwestern BMG and SQE community who’ve taught us so much how to molecularly dissect clinically complex problems.

Happy to share our latest work in Merkel cell carcinoma immunotherapy published today in Cancer Discovery Cancer Discovery from the Choi Lab Jaehyuk Choi in collaboration with the Tsai lab Kenneth Y. Tsai. aacrjournals.org/cancerdiscover…

Congratulations to Dr. Jaehyuk Choi, Jaehyuk Choi Zachary Reinstein, Zachary Reinstein and team on their recent publication in Cancer Discovery! Cancer Discovery Discovering a potential biomarker in rare skin cancer. #skincancer Northwestern Feinberg School of Medicine news.feinberg.northwestern.edu/2024/07/26/sci…