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Our paper with Cyclenium and David Thomas' group at McGill is out in Nature Communications: nature.com/articles/s4146… These macrocycles expand the chemical tool box for the stabilization of 14-3-3 PPIs and show some nice activity in rescuing mutant CFTR activity.

Our founders Luc Brunsveld and @COttmann1533 caught up with Innovation Origins to share our story and quest to create a protein interaction-based drug revolution: bit.ly/3STdNac

Happy to report that the paper on molecular glues of the 14-3-3/GR interaction with our friends from AZ Moelndal is out in JMedChem: pubs.acs.org/doi/full/10.10…

New Today! Induced Proximity group at Amgen 🧪🔬🧬 publish in RSC Chemical Biology on Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction. tinyurl.com/5n95hz79. Main conclusions… 1/thread

Great talk by Christian Ottmann at the LED3 hub (inactive account) Talks. He told us about his group's research into the stabilization of protein-protein interactions with small molecules (molecular glues) on the example of 14-3-3 protein complexes. Check out their latest paper: doi.org/10.1021/acscen…

Check out our paper on target identification of 14-3-3 clients after combined IFN and Fusicoccin treatment: authors.elsevier.com/a/1g-yb8jWWJtX…

Our co-founders, Luc Brunsveld, Michelle Arkin & Christian Ottmann recently published a paper on a molecular lock approach that enables the stabilization of protein complexes. These advances support the discovery and modeling of molecular glues. Read it here: bit.ly/42dkTfa

Check out our new paper in Angewandte with the first (to our knowledge) molecular glue from a linked fragment. Thanks for again a great collaboration between Eindhoven University of Technology and UCSF! onlinelibrary.wiley.com/doi/10.1002/an…

We have another story out from our ongoing collaboration between TU Eindhoven and UCSF, describing in JACS how we optimized a non-selective molecular glue fragment towards selectivity for ERalpha binding to 14-3-3. pubs.acs.org/doi/10.1021/ja…

During the pandemic, what was the silver lining in the collaborative work in the Arkin and Renslo labs at UCSF and the Brunsveld and Ottmann labs at TUE? Michelle Arkin, Adam Renslo, Christian Ottmann Find out in their #TeamProfile ow.ly/AFna50Q2sHu

Awesome paper from Dan Nomura showing the first YAP/TAZ — 14-3-3 molecular glues! Building off of seminal work by Michelle Arkin Christian Ottmann Interestingly, these glues can be incorporated into bifunctionals to alter the localization of BRD4!

Hoogleraar Luc Brunsveld vindt dat universiteiten terughoudend moeten zijn met politieke standpunten. "Onderwijs middels excellent, niet-activistisch, onderzoek lijkt mij op de lange termijn veel waardevoller om de richting van Nederland te beïnvloeden." cursor.tue.nl/opinie/columni…

Check out our review on the structural biology of molecular glues written with friends from RevMed: sciencedirect.com/science/articl…

Our story with the groups of Don Scott and Markus Kaiser on Molecular Glues of the 14-3-3/ChREBP complex is out in Nature Communications: Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity | Nature Communications