Get to know the 2024 AACR Journal Award winners, read their impactful articles, and tune in for their interviews to learn more about their work. bit.ly/3Xmf7Yu

Now online in Cancer Discovery: #MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in #BreastCancer - by Jitendra K Meena, Trey Westbrook and colleagues doi.org/10.1158/2159-8… BCMHouston

From the August issue: Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells. bit.ly/3yN4ip3 Gabriele Picco Mathew Garnett Garnett Lab Wellcome Sanger Institute

From the August issue: BRCA1-mediated Dual Regulation of #Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-inhibition in BRCA1-deficient Cancers. bit.ly/3T7n0P0 Guang Lei, Boyi Gan, PhD and colleagues MD Anderson Cancer Center

Another interesting paper today - congrats to Garnett Lab - this target came out of a gwCRISPR screen in MSI cell lines. No one expected it so it is great to see a small molecule inhibitor have an effect, particularly in IO resistant lines!

From the August issue: ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer. Ping Mu 🇺🇦 PCF Science UTSW Simmons Cancer Center. bit.ly/3MqdTVP

Condensate-Promoting ENL Mutation Drives Tumorigenesis in vivo through Dynamic Regulation of Histone Modifications and Gene Expression, Yiman Liu, Qinglan Li, Liling Wan, and colleagues. Penn Medicine Penn Medicine - Abramson Cancer Center Penn Epigenetics Univ. of Pennsylvania Department of Cancer Biology bit.ly/4cTwIvw

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News—BRAF–MEK Inhibitor Combo OK’d in Europe for NSCLC. bit.ly/4g7SoH1?

Read Cancer Discovery's #ResearchWatch: Macrophages Scavenge Myelin to Support Glioblastoma Metabolism. bit.ly/4790Rpr

Friends! I am super-excited to share our story on KLHL6 in this @BCD_aacr 📣KLHL6 targets the B-cell receptor and lymphoma mutations perturb this homeostasis! 🔓Read doi.org/10.1158/2643-3… 🪩Joint editorial in Cancer Discovery doi.org/10.1158/2159-8… 🧵Let’s go

August Editors’ Picks from the 10 AACR journals include a “colon-age” metric for personalizing colorectal cancer screening, a look at how violent environments affect stress signaling in lung tumors, and more. Learn more on the #AACRBlog: bit.ly/3XsWRge

Read the article: Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity. bit.ly/3Xu17fe

Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate #Glioblastoma Growth through Stabilizing BRD2, Lishu Chen, Qinghui Qi, Xiaoqing Jiang, Jin Wu, Tao Zhou, Jianghong Man, et al. bit.ly/3zh7CZz #NanhuLaboratory #NationalCenterofBiomedicalAnalysis.

I'm super excited to see our work featured on the cover art of the September issue of Cancer Discovery Cancer Discovery. aacrjournals.org/cancerdiscover… Artwork by Bianca Dunn

AACR NextGen Star Future Directions commentary is out! Thank you to the AACR for this fantastic opportunity to write about integration of immune profiling into epidemiologic studies #epitwitter aacrjournals.org/cancerdiscover…