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Four years after the 2020 Method of the Year (“spatially resolved transcriptomics”), Nature Methods has now nominated “spatial proteomics” as the 2024 Method of the Year. H/T Rong Fan (spatial guru!)

1/ Congrats to Sunita Keshari and all authors on our publication, where we interrogated tumor microenvironment (TME) remodeling induced by neoantigen (NeoAg) cancer vaccines and αPD-1, αCTLA-4 ICT, uncovering a more effective NeoAg vaccine-based combo preclinical therapy.

Published on Christmas day 🎁, our (@mzepedar & Susan Bullman) final paper of 2024 "Fusobacterium sphaericum sp. nov., isolated from a human colon tumor adheres to colonic epithelial cells and induces IL-8 secretion" tandfonline.com/doi/full/10.10…

1/ Out today in Cancer Cell our work on spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts (CAFs)! Led by the brilliant yunhe liu with key contributions from Anirban Maitra Humam Kadara and many collaborators MD Anderson Cancer Center cell.com/cancer-cell/fu…

Beautiful work on Fusobacterium and CRC by Jessica Queen, MD PhD, Drewes & Sears teams. “Biofilms were prevalent on colon tumors visualized in 68.8% ….more frequently observed on right-sided tumors (91.7%)”. biorxiv.org/content/10.110…

It was a quite a transformative experience to attend the inaugural Microbiome Accelerator from NatureAwards and Seed Health in London last year. Highly recommend entrepreneurial microbiome scientists to apply for the 2025 cycle! nature.com/articles/d4247…

Powerful new story from the Srivastava Lab Shivani Srivastava

Thrilled to share our latest study just out in nature 😄A major milestone in our collaboration with ⁦Anirban Maitra⁩ Led by brilliant ⁦⁦⁦Guangsheng Pei⁩ ⁦⁦⁦⁦⁦⁦⁦⁦⁦⁦⁦Jimin Min⁩ ⁦⁦MD Anderson Cancer Center⁩ nature.com/articles/s4158…

Wonderful work Linghua Wang, MD, PhD, Anirban Maitra and team! 👏

Looking forward to presenting and hearing from the other speakers this evening angel chagolla, at the microbiota and cancer prevention, diagnosis, and treatment session! Room S105 MD Anderson Cancer Center

Second paper on HMGA2 mediated basal identity in #PancreaticCancer from Sita Kugel Fred Hutch Cancer Center. This one is an elegant mechanistic dissection of the multi step cascade through which HMGA2 overexpression orchestrates basal lineage state: nature.com/articles/s4146…

If your stack of images is full of defects, don't panic! InterpolaAI, a deep learning-based optical flow method, will fix issue tears, photobleaching and sticking artifacts for improved 3D imaging. Read our paper in Nature Methods: nature.com/articles/s4159…

What exactly does "Fusobacterium nucleatum" refer to? It depends who you ask (and when you asked them). Our new perspective on taxonomy and naming challenges @GutMicrobes, proposing a genomics-based framework for Fusobacterium species designations. 🦠 tandfonline.com/doi/full/10.10…

Our team is hiring! 🦠 🧫 🥼🧑‍🔧 jobs.mdanderson.org/search/jobdeta…

Spatial Total RNA Sequencing of Formalin-Fixed Paraffin Embedded Tissues by spRandom-seq biorxiv.org/content/10.110…

Stromal lipid species dictate melanoma metastasis and tropism dlvr.it/TLK2RT

Absolutely insane amount of data in this resource from Chris Mason The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs biorxiv.org/content/10.110… Spatial data on 15million cells from 100 donors across multiple ages, mainly GI

I’m happy to share our latest work on tumour necrosis! During my time in the Mikala Egeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) nature.com/articles/s4158…

These findings add to the increasing evidence that cancer is not driven solely by DNA mutations. 🧵

New from the Bullman Lab in Cancer Cell! Tumor-infiltrating bacteria, including Fusobacterium, disrupt cell-cell contacts & trigger quiescence, uncovering a pathway of bacteria-induced therapy resistance 🔗 cell.com/cancer-cell/fu… Thanks to MD Anderson Cancer Center, @FredHutch, @UTEPnews