Foxp3 associates with Ikzf1 to form a repressive complex that promotes functional stability of Treg cells to prevent fatal autoimmune disease Immunity cell.com/immunity/fullt…

Excited to share Deep-STARmap and Deep-RIBOmap! We enabled spatial transcriptomic and translatomic mapping of >1K genes in 200 µm thick tissue and neuron morphology co-profiling. Thanks Xiao Wang for unwavering support; Jennifer for human skin study! biorxiv.org/content/10.110…

Lysosomal control of the cGAS-STING signaling: Trends in Cell Biology cell.com/trends/cell-bi…

Type I IFN is a critical pacesetter for immunometabolic checkpoints, nitric oxide and lactate, that determine macrophage bioenergetics and guide inflammation resolution during #MRSA infection Cell Reports Mary O'Riordan cell.com/cell-reports/f…

FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation Cell Reports cell.com/cell-reports/f…

The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response dlvr.it/TBk62d

Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells. journals.aai.org/jimmunol/artic…

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation dlvr.it/TBlKsk

Transformers in single-cell omics: a review and new perspectives nature.com/articles/s4159…

Comprehensive atlas of immune responses to low-dose IL-2 immunotherapy in SLE #lupus patients and identified distinct IL-2-driven Treg activation and tissue-homing programs Immunity cell.com/immunity/fullt…

Online now: Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics dlvr.it/TBqHmK

scTaILoR-seq advances RNA research by enabling detailed analysis of RNA isoforms at the single-cell level, offering new insights into gene expression and disease. #Genomics #RNASeq #CancerResearch Genentech rna-seqblog.com/sctailor-seq-s…

Our paper describing variability in cell type-specific gene regulatory programs in the pancreas in physiology and relationship to diabetes risk using single cell multiome profiling multiome.isletgenomics.org Hannah Mummey Weston Elison biorxiv.org/content/10.110…

ONLINE NOW: Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements dlvr.it/TC021D

We published a review on the advancements in the use of stem cell-derived islets (SC-islets) for diabetes research and treatment. Congrats Marlie Maestas and Maggie Bui! academic.oup.com/stcltm/advance… WUSM Department of Medicine @WUSTLdbbs WashU Endocrinology, Metabolism & Lipid Research

Our new preprint presents 3D light-sheet imaging of the intact islet, focusing on β-cell subpopulations that lead and coordinate islet Ca2+ oscillations. Great collaboration between Erli Jin, Jennifer Briggs, and Richard Benninger . biorxiv.org/content/10.110…

Our story on the discovery of enhancers of core pancreas-specifying transcription factors is out in Cell Reports bit.ly/3T77zGz IGVF 4DNucleome Consider joining us if you are interested in enhancers, human disease and #stemcell

Online now! Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution dlvr.it/TCwKg0

A new generation of vaccine #adjuvants tailored for the pediatric immune system could help overcome longstanding gaps in the design of #InfectiousDisease vaccines for children, according to a new Viewpoint from researchers at NIAID News. scim.ag/8hu

Webb-Robertson et al. show that alternative RNA splicing events in whole blood are significantly enriched in individuals with new-onset #type1diabetes and can effectively distinguish these individuals from unaffected controls. doi.org/10.1210/clinem…