🔥 hot off the press 🚨
Sink your teeth 🦷 into the latest #glycotime 🍭 research by Peng Wu Scripps Research describing bispecific T cell engager (BiTe) therapies targeting the #Siglec #SialicAcid immune axis 🎯 ♦️ nature.com/articles/s4155…

“…we discovered that the LPS receptor Toll-like receptor 4 ( #TLR4 ) is specifically dependent on the oligosaccharyltransferase complex OST-A for N-glycosylation and cell-surface localization” #glycotime cell.com/cell/fulltext/…

Researchers have created hybrids of biological motor protein and nonmotor #DNA binding domains that walk unidirectionally on synthetic DNA tracks containing the recognition sites for the DNA binding domains.

📄: scim.ag/6KE #SciencePerspective #ScienceMagArchives

Congrats to Ines Forrest, a fourth-year grad student in Chris Parker lab, on being named a 2024 CAS #FutureLeader from the American Chemical Society, an honor given annually to only 35 graduate students and postdoctoral researchers worldwide.🌟

More: ow.ly/loo450Rnp38

Towards planet-compatible chemicals! Check out our latest research where we use E. coli to convert methanol to industrially relevant molecules.
#ClimateCrisis #GreenChemicals #syntheticbiology
nature.com/articles/s4192…

Cool new paper in Cell that ties together two fundamentals of cancer biology: cancer cells have high levels of lactate (due to the Warburg effect), and almost always find a way to inactivate the cell's best tumour suppressor, p53

Zong et al. found that lactate, from the…

Cyclopropenes as Chemical Reporters for Dual Bioorthogonal and Orthogonal Metabolic Labeling of DNA (Hans-Achim Wagenknecht and co-workers) KIT Karlsruhe #openaccess #BioorthogonalChemistry onlinelibrary.wiley.com/doi/10.1002/an…

Surprisingly, it turns out you can place aromatic rings directly on RNA 2'-hydroxyls in water.
doi.org/10.1002/anie.2…

N-acetyllactosamine extension of complex N-glycans is a mechanism to evade lysis by NK cells
Cell Reports #LongLab doi.org/10.1016/j.celr…

YIKES

Time to ditch BioRender? I had no idea they were claiming copyright to the figures we make with it, even after we pay for use of the service.

📢WHAT DO WE WANT?!

MUCINS!

WHEN DO WE WANT'EM?!

NOW!

YOU ASKED FOR IT!! dr. mia | גילי Rommie Amaro and I have a new preprint out documenting our all-atom modeling and simulation of respiratory MUCINS!!!

Please read and give constructive feedback!! biorxiv.org/content/10.110…

Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancer Nature Communications
nature.com/articles/s4146…

A new computational approach to de novo protein design enables the creation of drug-binding proteins with accurate design and prediction binding energy and specificity, researchers report in Science.

📄: scim.ag/6Ad

Thank you ARCS Foundation Inc. ARCS Foundation – San Diego for supporting my research endeavors in grad school and beyond 🚀 ♦️

society if graphpad prism files had folders

great writeup on Ines Forrest
magazine.scripps.edu/awards-and-hon…

Our new proximity labeling technology is now published!!

This new subgroup is doing some amazing work - more to come!

nature.com/articles/s4155…

During a solar eclipse, the gaps between leaves on trees act as multiple pinhole cameras,

and each gap projects its own crescent-shaped image of the eclipsed sun onto the ground.

📹gottigreen

Your annual reminder to avoid azide reactions in DCM
#ChemTwitter #ChemSafety
pubs.acs.org/doi/full/10.10…