For this first time disclosures session : Birgit Wilding from Boehringer Ingelheim is sharing with us the discovery of the clinical candidate BI-1810631 (zongertinib) as selective HER2 inhibitor for the treatment of HER2 exon 20 insertion driven tumors #EFMCASMC23

#OnTheCover: Ligand 1H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution onlinelibrary.wiley.com/doi/10.1002/cp… Moriz Mayer Jark Boettcher Darryl B McConnell Pedro A. Sánchez-Murcia Aleksandra Ptaszek onlinelibrary.wiley.com/doi/10.1002/cp…

In einer kleineren Runde mit Verstärkung aus Mönchengladbach sprachen wir über das Remis der Lilien ebendort. Danke an 𝙮𝙫𝙤𝙣𝙣𝙚 ✨ für die Unterstützung. Direkt hier nachhören: 6vcl6z.podcaster.de/derlilienpodca… oder in eurem Podcatcher #bmgsvd #svd #sv98

Going after transcription factors is on the rise. onlinelibrary.wiley.com/doi/10.1002/ar…

Innovation and Team Spirit: The Magic of Science Competitions Seen through the Lens of the Compound Challenge Paper in Angewandte Chemie Internation Edition describing the Merck Compound Challenge - who is able to predict the best synthetic pathway? lnkd.in/eWg9PP9G

Ligandability assessment of the C-terminal Rel-homology domain of NFAT1 onlinelibrary.wiley.com/doi/full/10.10…

📢 👏 Cheryl Arrowsmith, Matthieu Schapira and Dalia Barsyte have been awarded more than $3 million from CIHR. Read more: bit.ly/3P5KZfj #CancerResearch #DrugDiscovery #ChemicalProbes, #AI

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria nature.com/articles/s4146…

Use the pathway information of reactome to select molecules worth to be tested in your biological system. Give it a try: apps.thesgc.org/pmp/index.php Structural Genomics Consortium (SGC) EUbOPEN #Taget2035 #openscience

Targeted Dephosphorylation In Action!! Two studies by Jin-Feng Zhao and Abbie Brewer from the Sapkota Lab. Excellent collaboration with Kei Sakamoto. cell.com/iscience/fullt… and cell.com/iscience/fullt… MRC PPU University of Dundee UoD Life Sciences

Happy to be part of a multi-institutional effort through an academia-industry partnership in the systematic analysis of the WWE domain in human E3 ligases using our PAR labeling technology! nature.com/articles/s4200… Structural Genomics Consortium (SGC) Boehringer Ingelheim Johns Hopkins BMB University of Oxford University of Toronto

Great collaboration and exciting data. Check out FP and #NMR assays, crystal structures of HUWE1, TRIP12, and DTX1 WWE domains and the first fragment bound crystal structures. #openscience EUbOPEN #Taget2035

Direct RAS inhibitors turn 10 nature.com/articles/s4158…

In collaboration with Boehringer Ingelheim, we present a comprehensive toolbox to support the generation of small molecule binders and chemical probes for the WWE domain-containing E3 ligases. nature.com/articles/s4200…

Discover non-obvious chemical tools using the pathway information of your target (listed a.o. in UniProt) with “Probe My Pathway” apps.thesgc.org/pmp/index.php, Structural Genomics Consortium (SGC) EUbOPEN Chemical Probes Portal reactome #Taget2035 #openscience

Thrilled to share that, together with my colleagues Centre for Targeted Protein Degradation and collaborators Boehringer Ingelheim, we report Science Magazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/sc…

Boehringer Ingelheim Centre for Targeted Protein Degradation Will Farnaby Thank you Channing Der and Adrienne Cox for this thoughtful commentary on our work - we appreciate your perspective: KRAS takes the road to destruction | Science 8/8 science.org/doi/10.1126/sc…

Nach den Enthüllungen um FPÖ-Spitzenfunktionäre, die das verbotene SS-"Treuelied" sangen, haben wir soeben mit Bini Guttmann die Nationalräte Martin Graf & Harald Stefan sowie FPÖ Parlamentsklub-Direktor Norbert Nemeth & Ex-NRA Johann Gudenus wegen NS-Wiederbetätigung angezeigt.