Jark Boettcher (@boettcherjark) 's Twitter Profile
Jark Boettcher

@boettcherjark

Protein crystallography, Cryo-EM, FBS, SBDD and open science enthusiast. Tweets are my own. Also on mastodon: @[email protected]

ID: 1149207672400547840

calendar_today11-07-2019 06:43:55

575 Tweet

236 Followers

217 Following

EFMC (@euromedchem) 's Twitter Profile Photo

For this first time disclosures session : Birgit Wilding from Boehringer Ingelheim is sharing with us the discovery of the clinical candidate BI-1810631 (zongertinib) as selective HER2 inhibitor for the treatment of HER2 exon 20 insertion driven tumors #EFMCASMC23

For this first time disclosures session : <a href="/birgitwilding/">Birgit Wilding</a> from <a href="/Boehringer/">Boehringer Ingelheim</a> is sharing with us the discovery of the clinical candidate BI-1810631 (zongertinib) as selective HER2 inhibitor for the treatment of HER2 exon 20 insertion driven tumors

#EFMCASMC23
ChemPhysChem (@chemphyschem) 's Twitter Profile Photo

#OnTheCover: Ligand 1H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution onlinelibrary.wiley.com/doi/10.1002/cp… Moriz Mayer Jark Boettcher Darryl B McConnell Pedro A. Sánchez-Murcia Aleksandra Ptaszek onlinelibrary.wiley.com/doi/10.1002/cp…

#OnTheCover: Ligand 1H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution onlinelibrary.wiley.com/doi/10.1002/cp… <a href="/morizmayer/">Moriz Mayer</a> <a href="/BoettcherJark/">Jark Boettcher</a> <a href="/D_B_McConnell/">Darryl B McConnell</a> <a href="/psanmur/">Pedro A. Sánchez-Murcia</a> <a href="/ptaszeg6/">Aleksandra Ptaszek</a> onlinelibrary.wiley.com/doi/10.1002/cp…
Hoch und weit (@hoch_und_weit) 's Twitter Profile Photo

In einer kleineren Runde mit Verstärkung aus Mönchengladbach sprachen wir über das Remis der Lilien ebendort. Danke an 𝙮𝙫𝙤𝙣𝙣𝙚 ✨ für die Unterstützung. Direkt hier nachhören: 6vcl6z.podcaster.de/derlilienpodca… oder in eurem Podcatcher #bmgsvd #svd #sv98

In einer kleineren Runde mit Verstärkung aus Mönchengladbach sprachen wir über das Remis der Lilien ebendort. Danke an <a href="/polyvalenz/">𝙮𝙫𝙤𝙣𝙣𝙚 ✨</a> für die Unterstützung. 
Direkt hier nachhören: 6vcl6z.podcaster.de/derlilienpodca… oder in eurem Podcatcher

#bmgsvd #svd #sv98
Ulrich Betz (@ulrichbetz) 's Twitter Profile Photo

Innovation and Team Spirit: The Magic of Science Competitions Seen through the Lens of the Compound Challenge Paper in Angewandte Chemie Internation Edition describing the Merck Compound Challenge - who is able to predict the best synthetic pathway? lnkd.in/eWg9PP9G

Innovation and Team Spirit: The Magic of Science Competitions Seen through the Lens of the Compound Challenge
Paper in Angewandte Chemie Internation Edition describing the Merck Compound Challenge - who is able to predict the best synthetic pathway?
lnkd.in/eWg9PP9G
Jark Boettcher (@boettcherjark) 's Twitter Profile Photo

Use the pathway information of reactome to select molecules worth to be tested in your biological system. Give it a try: apps.thesgc.org/pmp/index.php Structural Genomics Consortium (SGC) EUbOPEN #Taget2035 #openscience

Alex Waterson (@agwaterson) 's Twitter Profile Photo

BI-0474 is a novel, covalent inhibitor of KRAS G12C, discovered by a Vanderbilt UniversityBoehringer Ingelheim collaboration by first optimizing weakly binding fragment hits. You can order it for free on opnMe: bit.ly/3QUJKRe

BI-0474 is a novel, covalent inhibitor of KRAS G12C, discovered by a <a href="/VanderbiltU/">Vanderbilt University</a>, <a href="/Boehringer/">Boehringer Ingelheim</a> collaboration by first optimizing weakly binding fragment hits. You can order it for free on opnMe: bit.ly/3QUJKRe
Anthony Leung (@leunglab) 's Twitter Profile Photo

Happy to be part of a multi-institutional effort through an academia-industry partnership in the systematic analysis of the WWE domain in human E3 ligases using our PAR labeling technology! nature.com/articles/s4200… Structural Genomics Consortium (SGC) Boehringer Ingelheim Johns Hopkins BMB University of Oxford University of Toronto

Jark Boettcher (@boettcherjark) 's Twitter Profile Photo

Great collaboration and exciting data. Check out FP and #NMR assays, crystal structures of HUWE1, TRIP12, and DTX1 WWE domains and the first fragment bound crystal structures. #openscience EUbOPEN #Taget2035

Structural Genomics Consortium (SGC) (@thesgconline) 's Twitter Profile Photo

In collaboration with Boehringer Ingelheim, we present a comprehensive toolbox to support the generation of small molecule binders and chemical probes for the WWE domain-containing E3 ligases. nature.com/articles/s4200…

Jark Boettcher (@boettcherjark) 's Twitter Profile Photo

Discover non-obvious chemical tools using the pathway information of your target (listed a.o. in UniProt) with “Probe My Pathway” apps.thesgc.org/pmp/index.php, Structural Genomics Consortium (SGC) EUbOPEN Chemical Probes Portal reactome #Taget2035 #openscience

Alessio Ciulli (@alessiociulli) 's Twitter Profile Photo

Thrilled to share that, together with my colleagues Centre for Targeted Protein Degradation and collaborators Boehringer Ingelheim, we report Science Magazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/sc…

Alessio Ciulli (@alessiociulli) 's Twitter Profile Photo

Boehringer Ingelheim Centre for Targeted Protein Degradation Will Farnaby Thank you Channing Der and Adrienne Cox for this thoughtful commentary on our work - we appreciate your perspective: KRAS takes the road to destruction | Science 8/8 science.org/doi/10.1126/sc…

Jüdische österreichische Hochschüler:innen (@joehwien) 's Twitter Profile Photo

Nach den Enthüllungen um FPÖ-Spitzenfunktionäre, die das verbotene SS-"Treuelied" sangen, haben wir soeben mit Bini Guttmann die Nationalräte Martin Graf & Harald Stefan sowie FPÖ Parlamentsklub-Direktor Norbert Nemeth & Ex-NRA Johann Gudenus wegen NS-Wiederbetätigung angezeigt.