PKN1 is a PKC-related #kinase that acts downstream of RhoA and Rac1 pathways. Lin and Yuan dig into the lipid binding/activation site of this unique kinase, revealing mechanistic details and providing a blueprint for inhibitors.

pubs.acs.org/doi/10.1021/ac…

中央研究院 Academia Sinica
University of Melbourne

Antifungal agents are critical to combat resistance and geographic spread of these pathogens.

Yona and Micha Fridman explore the mechanism of the fungal inhibitor poacic acid, revealing impacts on chitin production and metal homeostasis.

pubs.acs.org/doi/10.1021/ac…

Tel Aviv University

Crowding agents are used to mimic intracellular environments, capturing biomolecules in more native conditions.

Liebau et al. study the impact of different PEGs on tRNA synthetase, finding disparate impacts depending on length.

pubs.acs.org/doi/10.1021/ac…

UWEC Department of Chemistry and Biochemistry
Ohio State

Consensus sequences are used extensively to predict protein function.

Musila and Rokita offer a cautionary tale re this practice in their analysis of FMN-binding & catalytic residues in nitroreductases.

pubs.acs.org/doi/10.1021/ac…

#tbt
Johns Hopkins Arts & Sciences
@johnshopkins
#flavins

Photosynthesis pathways:

Quinone herbicides binding to type-II reaction centers of purple bacteria suggest a QB-mediated link between the electron transfer inactive branch and the proton uptake pathway.

From Ishikita and colleagues UTokyo | 東京大学

pubs.acs.org/doi/10.1021/ac…

Halting headaches:

Does the amylin 1 receptor play a role in migraines? @PatrickMSexton, Wootten & colleagues report a #cryoEM structure of AMY1R with the peptide CGRP & Gs protein, revealing new insights.

pubs.acs.org/doi/10.1021/ac…

ARC CCeMMP
Monash Institute of Pharmaceutical Sciences
UTokyo | 東京大学
#GPCR

19F NMR tools:

Zondlo and colleagues show that 4,4-difluoroproline is a broadly applicable tool for monitoring Pro conformation with applications in protein folding, intramolecular interactions and intrinsic disorder.

pubs.acs.org/doi/10.1021/ac…

#folding
#disorder
Univ. of Delaware

📢 Call for Papers!

Biased Signaling is an upcoming Special Issue in Biochemistry organized by Executive Editor Bryan Roth (BryanRoth)

Learn more here and get your research seen by the global #Biochemistry community ➡ go.acs.org/91r

Make sure you check out the fantastic artwork on the Issue #4 front cover!

Learn the significance of this work in Kwanwoo Shin's Editorial in #ACSSyntheticBiology ➡️ go.acs.org/8Zr

'Scientific progress relies on the maxim that scientific inquiry knows no bounds' 🤩

How does a mixed-valent diiron oxygenase help in the #biosynthesis of a copper chelator?

Rosenzweig Lab, Hoffman and colleagues Northwestern use ENDOR to look at substrate binding, revealing the initial steps toward methanobactin.

pubs.acs.org/doi/10.1021/ac…

#bioinorganic

CO2 impacting signaling:

Pawloski et al expand on initial reports of ubiquitin carbamylation, testing susceptibility of all amines & finding candidates that likely affect polyUb-mediated pathways in cells.

pubs.acs.org/doi/10.1021/ac…

#tbt
#PTM
Univ. of Maryland
Johns Hopkins Arts & Sciences

Aldehyde dehydrogenases are of interest in understanding disease and #biocatalysis .

Soulimane, Luis Padrela and colleagues University Of Limerick examine an unusual C-terminal extension found in thermophilic ALDHs, finding impacts on kinetics, stability & specificity.

pubs.acs.org/doi/10.1021/ac…

Did you know that the world’s deadliest animal is the #mosquito ? A path towards new super-specific insecticides takes advantage of the unique biochemistry of mosquito larvae guts, as published in J. Am. Chem. Soc.. Read more: brnw.ch/21wIQxE ACS Publications #Research

New issue! 📣

Read up on enhanced antibodies, microsatellites, proteasomes, ethylene formation, chitin production, and more!

pubs.acs.org/toc/bichaw/63/8

Cover image: Auchus and colleagues University of Michigan explore how P450 11B2 catalyzes 3 consecutive oxidations.

pubs.acs.org/doi/10.1021/ac…

A three-continent collaboration explores the potential convergent evolution of glucanases, critical for grain germination in barley.

pubs.acs.org/doi/10.1021/ac…

#glycotime
#plantbiochemistry
#proteinevolution
KTH Royal Institute of Technology
Taipei Medical University
@uniofadelaide
IBM Research
University of Auckland | Waipapa Taumata Rau

ICYMI: @Sasa10447 et al unravel the catalytic mechanism of an important antioxidant enzyme from M. tuberculosis, revealing how sulfoxides are reduced.

Now an #ACSEditorsChoice paper!

pubs.acs.org/doi/10.1021/ac…

#mycobacteria

Toward plastic recycling:

@courtadegaston and colleagues characterized a PET-hydrolyzing cutinase from Fusarium solani pisi, revealing opportunities to improve enzyme activity and tune degradation products.

pubs.acs.org/doi/10.1021/ac…

#biocatalysis
#tbt
NTNU
Aalborg Universitet

📢 Call for Papers!

Biased Signaling is an upcoming Special Issue in Biochemistry organized by Executive Editor Bryan Roth (BryanRoth)

Learn more here and get your research seen by the global #Biochemistry community ➡ go.acs.org/8R1

The enzyme EFE can form ethylene or hydroxylate Arg (en route to guanidine), both of biotechnological interest.

Chatterjee et al use substrate analogs and mutants to dig into active site interactions, enabling future applications.

pubs.acs.org/doi/10.1021/ac…

#metalloenzymes

Cell death mechanisms:

Zhu and colleagues The Chinese University of Hong Kong - CUHK show 4-hydroxyestrone protects against ferroptotic cell death and binds to protein disulfide isomerase, providing further support that PDI is a meaningful target to prevent ferroptosis.

pubs.acs.org/doi/10.1021/ac…

#cancer