Improving Tox Assay Predictability with Physioxia: Human renal proximal tubular epithelial cells exhibit in vivo-like properties in co-culture under physiological oxygen, Piossek et al. report. Read more: pubmed.ncbi.nlm.nih.gov/35533734/ #Cytocentric #Cellculture #hypoxia #physioxia #Tox

Oxygen Controls the Lymphovascular-Immune Ensemble: Schito et al. review the role of hypoxia in the lymphatic system's response to cancer. Read more: cell.com/trends/cancer/…? #Cytocentric #Cellculture #hypoxia #physioxia #Lymphatic

Enhanced Self-Renewal of HSC Under Physioxia: Physioxia induces downregulation of Tet2 in Hematopoietic Stem Cells, report Aljoufi et al. Read more (open access): ashpublications.org/blood/article/… #Cytocentric #Cellculture #HSC #hypoxia #physioxia

Altering O2 in Solid Tumor Studies: Herrera-Campos et al. review the role of hyperoxia and the immune system in novel treatments for solid tumors. Read more (open access): mdpi.com/2072-6694/14/1… #Cytocentric #Cellculture #Cancer #hypoxia #physioxia

Physioxia Influences Gene Methylation: Dogan et al. use physiological oxygen to examine epigenetic modification in pluripotent stem cells. Read more (open access): ncbi.nlm.nih.gov/pmc/articles/P… #Cytocentric #Cellculture #hypoxia #physioxia

Simulating Pathological Hypoxia to Study Neurodegeneration: Thinard et al. discuss a novel approach to therapy at the blood brain barrier. Read more (open access): mdpi.com/1999-4923/14/7… #Cytocentric #Cellculture #BBB #hypoxia #physioxia

Physioxia Diminishes Cellular Iron Dependency: New biosensors uncover altered cell metabolism in this study by Sevimli et al. Read more (open access): sciencedirect.com/science/articl… #Cytocentric #Cellculture #Biosensing #Metabolism #hypoxia #physioxia

Mimicking the TME in Immunotherapy Studies: Ma et al. discuss drug resistance and epigenetic vulnerability in triple negative breast cancer. Read more (open access): pubmed.ncbi.nlm.nih.gov/35840558/ #Cytocentric #Cellculture #TME #Immunotherapy #hypoxia #physioxia

Hypoxia Improves MSC Therapeutic Potential: Silvestro et al. study congenital pulmonary airway malformations in infants and detail the role of hypoxia in therapeutic MSC applications. Read more (open access): pubmed.ncbi.nlm.nih.gov/35774062/ #Cytocentric #Cellculture #MSC #hypoxia

Photosynthetic Gel for Wound Healing: Zhu et al. mimic peripheral artery disease in vitro to develop a novel topical gel to enhance localized hyperoxygenation. Read more (open access): nature.com/articles/s4159… #Cytocentric #Cellculture #hypoxia #physioxia

B Cell Function, Development, and Metabolism are Regulated by HIF: A comprehensive review by Zhang et al. of immunoregulation by hypoxia and hypoxia-inducible factors. Read more (open access): frontiersin.org/articles/10.33… #Cytocentric #Cellculture #Bcell #HIF #hypoxia #physioxia

Goldilocks, Radiation, and Cataracts in Space: Richard B. Richardson details the role of oxygen in cataract development in US astronauts. Read more (open access): pubmed.ncbi.nlm.nih.gov/35917999/ #Cytocentric #Cellculture #cataract #oxygen #hypoxia #physioxia

Neuroinflammation Regulation Therapies Tested Using Hypoxia: Wang et al. recreate pathophysiological conditions to study neuroprotection after cardiac arrest-induced brain injury. Read more: pubmed.ncbi.nlm.nih.gov/35921049/ #Cytocentric #Cellculture #NSC #hypoxia #physioxia

Intestinal Wound Healing and HIF: Steiner et al. review the double-edged sword HIF present over the course of the metabolic response to chronic intestinal inflammation. Read more: pubmed.ncbi.nlm.nih.gov/35912990/ #Cytocentric #Cellculture #HIF #hypoxia #physioxia #metabolism

We are so thrilled to share this news! phiab.com/pressrelease/p… #regenerativemedicine #biomanufacturing #celltherapies #holomonitor BioSpherix, LLC QIAGEN Wake Forest Institute for Regenerative Medicine SAS Software

Identifying EV Uptake Signals in Pancreatic Cancer: Nigri et al. mimic pathophysiologic conditions to identify a potential target for therapeutic intervention into aggressive PDAC. Read more (open access): pubmed.ncbi.nlm.nih.gov/35917363/ #Cytocentric #Cellculture #hypoxia #physioxia

Osteogenesis and HIF Signaling in the Clinic: An in-depth review of recent progress in HIF-regulated bone regeneration provides evidence for novel tissue repair strategies. Read more: pubmed.ncbi.nlm.nih.gov/35913258/ #Cytocentric #Cellculture #tissueeng #hypoxia #physioxia

How do we measure parameters for biofabricated tissues? What critical aspects of tissue engineered products remain unmonitored? Join us Dec 1st at NIST's virtual workshop to discuss measurement needs, future directions, and more. nist.gov/news-events/ev…

Have your cell cultures been naughty this year, or nice? Happy Holidays, from the BioSpherix family.

Join us at ASME's free webinar to discuss exciting advancements in biomedical innovation! Register now: asme.zoom.us/webinar/regist…