Baumjohann Lab
@baumjohannlab
Research on T helper cells in #Immunity and #Autoimmunity in the lab of Dirk Baumjohann #TfhCells #GerminalCenters @ImmunoSens @UniklinikBonn @UniBonn
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https://baumjohannlab.de 08-11-2019 09:34:06
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CXCL13 shows up prominently in T cells in autoimmune tissues and tumors. Human Tfh and Tph cells produce lots of CXCL13, yet its regulation is pretty unclear. With beautiful CRISPR screens by Jaehyuk Choi, Calvin Law, we found a few key factors... nature.com/articles/s4158…
Excited to see the last chapter of my #PhD published today Nature Immunology. This was a perfect collaboration with my friend Pratiksha Thakore. We analyzed the chromatin landscape of Th17 cells and identified BACH2 as an important regulator. nature.com/articles/s4159…
REVIEW Nature Immunology Caitlin Zebley, MD PhD T cell dysfunction and therapeutic intervention in cancer nature.com/articles/s4159…
Sharing our latest paper by Arti Medhavy & Vicki Athanasopoulos. Underscores the value of: i) discovery of rare gene variants in children with ambiguous diagnoses of autoimmunity; ii) collaboration between The Crick, John Curtin School of Medical Research, ANU, & Shanghai Renji Hospital - Nan Shen nature.com/articles/s4159…
TGFβ inhibits development of intestinal TH17-dervied cells that induce cancerous transformation of intestinal epithelium not via IL-17, but in KLF6/T-BET/IFN-γ-dependent manner Nature Immunology Valentin Thevin julien C. Marie nature.com/articles/s4159…
Synergy between LAG-3 and PD-1 in subversion of CD8 T cell effector function Cell Vignali Lab E. John Wherry Tony Cillo, PhD Tullia Bruno, PhD cell.com/cell/fulltext/… cell.com/cell/fulltext/… cell.com/cell/fulltext/… cell.com/cell/fulltext/…
Two new papers report the specificity & differentiation dynamics of human LN TFH cells after flu or COVID vaccines. The flu paper is a collab. between my lab (stefan.schattgen ) & Ali Ellebedy, while the COVID was led by Ali, Philip Mudd, and Nick Borcherding-a 🧵nature.com/articles/s4159…
Discovered 30 years ago, CD40L antagonists are proving to be powerful autoimmune drugs Science Magazine science.org/doi/10.1126/sc…
New from us In the 2024 Current Opinion in Immunology: Tumour Immunology section, Benjamin Broomfield and I contrast the stem-like T cell niche in LN and TME to understand how to enhance vaccination and immunotherapy Many thanks to Stefani Spranger for the invite sciencedirect.com/science/articl…