The ECM isn’t just an innocent bystander... We join forces with Biton Lab in this new @bioaRxivpreprint on how lasting #ECM damage, “modECM”, pushes intestinal stem cells into a wound associated pro-inflammatory state! biorxiv.org/content/10.110…

Kanvas Biosciences, founded by Cornell University researchers, is advancing microbiome therapeutics with HiPR-FISH, a tool to map gut bacteria at single-cell precision. Their lead drug KAN-001 outperformed mice stool transplants and is heading to trials! Read More: bit.ly/3SMpfqy

Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling cell.com/cell/abstract/… Cell

Today in nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a

Editors must have a VERY clear understanding of what exactly journals offer, in a world where when preprints can be both peer reviewed and collected/disseminated. Mandatory listening for the latest on this + a brief history of BioRxiv, + general thoughtfulness of Richard.

What if the blueprint for youth is never truly lost, just inaccessible? Today, we're excited to announce the publication of our "Cell Annealing" model in which cells can be rebooted to restore their optimal, youthful state and escape ageing. nature.com/articles/s4142…

a core tension in applying "virtual cell" models to therapeutic development is the mismatch between the scale at which we measure biology and the scale at which we intervene. we often measure at the cell level (eg single-cell RNA-seq), but we treat at the tissue or organ level

We conducted a study on 3691 people to empirically test 40 claims about IQ (including claims made in academia and by the general public)! Here are some of our most important findings (see the link at the bottom of this thread for all 40 results): 🧵

Evolution’s eye game is wild, but mollusks take it to another level Using CRISPR, we now have a new model in apple snails to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess Evolution, it turns out, doesn’t just innovate, it rewinds,

What’s the most mind-blowing paper you have ever read? I'll start: Williams 1957 on antagonistic pleiotropy. An amazing paper that shaped my work on programmatic theories of ageing and on how developmental processes beneficial early in life can be harmful at later stages.

Published now Genome Research how Xist upstream elements regulate gene expression. Excellent work by Sudeshna Majumdar Thanks IISc Bangalore Anusandhan National Research Foundation Department of Biotechnology EMBO YIP for support. genome.cshlp.org/content/early/…

Glucose triggers insulin release to power metabolism — can go awry in diabetes. Our PNASNews study tracks it down to single cells IISc Bangalore Longevity India Genesis DBG UppsalaUniLib Anusandhan National Research Foundation Department of Biotechnology ICMR Infosys Foundation India Novo Nordisk Foundation pnas.org/doi/10.1073/pn…

4. what’s inside this draw to video: - paint + animate in one place - works with all Veo 3, Seedance, MiniMax modes - stack Effects, Flux Kontext, UGC Builder - start/end frames, inpaint, tweak everything

If you are in Bangalore or surrounding area on 6th Sept - it would be fantastic to see you. We are starting a broader conversation on scaling up frugalscience.org - if you want to teach these principles in your classroom - pls reach out here.. Foldscope

Nietzsche, go for a walk

Wrote down some mostly comedic, possibly true thoughts about aging and longevity! Please read and share. #aging #longevity #biologyresearch #MedicalResearch open.substack.com/pub/tatagata/p…

my definitive alignment chart for memes where you choose between two things