Active nucleoli have the capability to release perinuclear heterochromatin, which is a novel event of iPSC reprogramming. onlinelibrary.wiley.com/doi/10.1111/cp…

TREM2 exacerbates spinal cord injury by inhibiting TFEB nuclear translocation, aggravating lysosomal membrane permeabilisation and consequently suppressing autophagy. onlinelibrary.wiley.com/doi/10.1111/cp…

This review explores NK cells' role in early pregnancy, covering molecular mechanisms and therapies. It also links NK cell dysfunction to RSA and RIF, offering insights for future research and clinical treatments. onlinelibrary.wiley.com/doi/10.1111/cp…

This review explores autophagy's dual role in cellular radiosensitivity during radiotherapy, detailing its survival-promoting and growth-suppressing mechanisms, and highlights emerging autophagy-targeted therapies. onlinelibrary.wiley.com/doi/10.1111/cp…

NSun2-mediated tRNA-derived small RNAs (tsRNAs) regulate liver fibrosis by inhibiting sinusoidal capillarization via the DUSP1/FAK pathway, offering new therapeutic targets. onlinelibrary.wiley.com/doi/10.1111/cp…

Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3-induced oxidative stress in HCC. onlinelibrary.wiley.com/doi/10.1111/cp…

Cy3-AptEGFR@BPNSs enables real-time, visual EGFR monitoring in cancer cells via fluorescence quenching/recovery for precise diagnosis and treatment. onlinelibrary.wiley.com/doi/10.1111/cp…

GSN+ inflammatory fibroblasts impair immunotherapy response by exhausting CD8+ T cells, with a new Caf.Sig model predicting outcomes and suggesting GSN boosting as a combo therapy. onlinelibrary.wiley.com/doi/full/10.11…

Welcome to join the 16th HOPE Young Scientist Forum online at 21:00 (GMT-4) on May 23 via Tencent Meeting meeting.tencent.com/dm/oqog50uuP5ag forward to the excellent talks! 🥳Host: Dr. Guihai Feng. Speakers: Dr. Dong Han, Dr. Xin Tang Xin Tang and Dr. Haijiao Liu Haijiao Liu

ROCK2 inhibition enhances osteosarcoma sensitivity to MPPa-PDT by suppressing autophagy via the Hippo pathway. onlinelibrary.wiley.com/doi/10.1111/cp…

CLEC3A, PCDH10, and ST3GAL1 promote endocrine resistance in ER+HER2− breast cancer via PI3K-AKT signaling, offering prognostic and therapeutic targets. onlinelibrary.wiley.com/doi/10.1111/cp…

This study created a reliable mouse model of melasma using UVB, progesterone, and stress, which mimics human melasma and responds to tranexamic acid, offering a tool for future research. onlinelibrary.wiley.com/doi/10.1111/cp…

MFG-E8 worsens abdominal aortic aneurysms by increasing oxidative stress via the ERK/NOX4 pathway, while resveratrol counteracts this effect, suggesting potential treatment benefits. onlinelibrary.wiley.com/doi/10.1111/cp…

Welcome to join the 17th HOPE Young Scientist Forum online at 14:00 (GMT+8) on July 31 via Tencent Meeting meeting.tencent.com/dm/azTNdL6HqF43 forward to the excellent talks! 🥳Host: Dr. Qiutan Yang Qiutan Yang

FAM20A insufficiency disrupts gingival fibroblast function, leading to gingival overgrowth in AI1G through altered cell adhesion, differentiation, proliferation, and apoptosis. onlinelibrary.wiley.com/doi/10.1111/cp…

ITGB2 promotes osteoclast differentiation in osteoarthritis via Rac1 activation, and its inhibition slows disease progression by suppressing bone resorption, revealing a potential therapeutic target. onlinelibrary.wiley.com/doi/10.1111/cp…

Despite mouse-specific amino acid changes in Cdx2's DNA-binding domain, its transcriptional effects remain conserved between rodents, revealing evolutionary plasticity in TF binding but stability in gene regulation. onlinelibrary.wiley.com/doi/10.1111/cp…

Kdf1 regulates molar cusp formation by controlling dental epithelial cell proliferation via the PI3K/AKT/mTOR pathway. onlinelibrary.wiley.com/doi/10.1111/cp…

PIK-III enhances cuproptosis in resistant renal cancer by restoring thiamine metabolism, redirecting glycolysis into the TCA cycle, and synergizing with elesclomol to induce metabolic crisis. onlinelibrary.wiley.com/doi/10.1111/cp…