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Big thanks to Professor Johan Auwerx Auwerx Lab for the insightful talk on mitochondria & aging at Kinderspital Zürich. We enjoyed that you highlighted the power of mouse data to enable human health trajectories. Your expertise in metabolism and genetics has left us inspired 🧬

Alessia de Masi and colleagues identify with Cyclo-His-Pro (CHP), a compound that improves muscle function in mouse models of Duchenne Muscular Dystrophy and Sarcopenia. Anti-inflammatory and anti-fibrotic mechanisms underpin this effect of CHP. onlinelibrary.wiley.com/doi/10.1002/ad…

Thanks to all the current and past collaborators which made this happen - #1 in Switzerland research.com/u/johan-auwerx

The work of Xiaoxu Li and collaborators defines a simple continuous and composite trait, termed the metabolic health score, that is more accurate in defining metabolic homeostasis and predicting future disease incidence sciencedirect.com/science/articl…

🧬🔬Our researchers at EPFL Life Sciences developed a metabolic health score using diverse mice strains, uncovering key genetic factors influencing metabolic health. Validated in human data, this study paves the way for personalized MetS treatments. go.epfl.ch/0b3455

Nos chercheurs ont développé un score de santé métabolique dévoilant des facteurs génétiques clés influençant la santé métabolique. Validée par des données humaines, cette étude ouvre la voie à des traitements personnalisés. go.epfl.ch/523d22

Li et al. derive a continuous biomarker for metabolic homeostasis, the Metabolic Health Score (MHS), which they find associated with 2 genetic loci in BXD mice, and identify TNKS and MCPH1 as modulators of MHS in human datasets Xiaoxu Li Auwerx Lab cell.com/cell-systems/f…

An interview by CQFD about our latest work Comment la génétique influence-t-elle notre santé métabolique? rts.ch/audio-podcast/…

Explore emerging research with field leaders Keystone Symposia Mitochondrial Biology in Health and Disease, this January in Taipei! keysym.us/KSMitochondria… #KSMitochondria25

Explore emerging research with field leaders Keystone Symposia Mitochondrial Biology in Health and Disease, this January in Taipei! youtu.be/dtI9i6iWBzs #KSMitochondria25

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan dlvr.it/TF4qn8

Following the exciting news of the 2024 Nobel Prize in Medicine awarded to Gary Ruvkun and Victor Ambros for their groundbreaking discovery of microRNA, particularly in the worm C. elegans, I’m thrilled to share a new resource we’ve just published at hashtag#CellReports! :D

Our work on the role of NAD+ de novo synthesis in MASLD is out in Journal of Hepatology! Journal of Hepatology Inhibiting ACMSD boosts liver NAD+ levels and reduces fibrosis, inflammation, and DNA damage in both mice and human liver organoids. Paper: journal-of-hepatology.eu/article/S0168-…

Congrats to Yasmine Liu & team for demonstrating ACMSD inhibition reduces liver inflammation and early fibrosis in MASLD! Boosting NAD+ and reducing DNA damage in the liver are key to its effects. Paper, journal-of-hepatology.eu/article/S0168-…

Researchers at Auwerx Lab (EPFL Life Sciences) have discovered that inhibiting the ACMSD enzyme can boost vital NAD+ levels, reducing liver inflammation and fibrosis in MASLD/MASH. This could pave the way for new treatments go.epfl.ch/rCO-en

Une nouvelle piste pour lutter contre la stéatose hépatique rts.ch/audio-podcast/…

Congratulations to Andrea Ablasser, Johan Auwerx Auwerx Lab, Gioele La Manno Gioele La Manno, and Matthias Lütolf Matthias Lutolf, who have made Clarivate's #HighlyCited2024 list! actu.epfl.ch/news/four-epfl…

We were selected again as a “Highly Cited Researcher” in 2024 by Clarivate. Thanks to all graduates for the hard work that enabled our continued success! actu.epfl.ch/news/four-epfl…

Another step in bringing ceramide lowering therapies to patients with muscle disease. Congratulations to Johanne, Ioanna, and Tanes Imamura de Lima for your valuable contributions pubs.acs.org/doi/10.1021/ac…

Thank X (Twitter) for providing us a nice platform to spread our scientific news. But we decided to stop maintaining our X account and move to Bluesky.