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New genetic analysis in 200k people over 14 years ▶️apoB + lp(a) best capture lipid-mediated CV risk ▶️LDL particle size adds no additional info when apoB is accounted for academic.oup.com/eurheartj/adva…

Should secondary SBP prophylaxis (SecSBPPr) still be given in cirrhosis? In 2 🇺🇸national cohorts (>11000 SBP patients), SecSBPPr⬆️the risk of SBP recurrence in multivariable analysis by 63%–68% vs no prophylaxis. And this trend worsened over time. doi.org/10.14309/ajg.0…

Plain English is doing a new mini-series on why Americans are so unhealthy. Today: IS ULTRAPROCESSED FOOD REALLY KILLING US? With nutrition scientist Kevin C. Klatt, PhD, RD, we discuss what makes food "ultraprocessed" and how UFPs drive overeating and chronic disease. This is the key

Daily oral and monthly injectable naltrexone given to hospitalized patients with alcohol use disorder did not differ in effectiveness for reducing heavy drinking days. ja.ma/4mEkZH3

📢 Essential Reading – 2025 Landmark Paper on Lp(a) The Brussels International Declaration on Lipoprotein(a) Testing and Management, published in Atherosclerosis, represents the most comprehensive and authoritative document on Lp(a) to date. ☝️Highlights: 1️⃣ Establishes global

NEW on the #AJKDBlog: Timothy Yau interviews Roger Rodby and Bill Whittier about all things RTA! Renal Tubular Acidosis: An Interview bit.ly/Rodby25 (FREE)

New data w/Rohit Loomba MASLD Research Center on extended-release naltrexone (XR-NTX) in advanced ALD: In this case series, XR-NTX was well tolerated in patients with compensated ALD (64% cirrhosis)— no hepatotoxicity, no severe adverse events. 👉 doi.org/10.1111/apt.70… #LiverTwitter

Genetic variants that reduce ApoB concentrations reduce the risk of coronary heart disease. The more they lower ApoB concentrations, the more they reduce the risk of heart disease. This is amazingly clear causal evidence.

🚨 Benzonatate can kill—but rarely by accident. Our 20‑year review , serious toxicity (seizure, dysrhythmia, death) was almost entirely seen in intentional cases. Unintentional? Nearly all walked away. Proud of former resident Dr Cicci for leading this! pubmed.ncbi.nlm.nih.gov/40511470/

Now in JACC Journals, Thijs Eijsvogels and colleagues find that most exercise induced troponin elevation is not explainable by CAD. jacc.org/doi/10.1016/j.… Meagan Murphy Wasfy and I contextualize these results in accompanying editorial Mass General Heart jacc.org/doi/10.1016/j.…

🧬 The Liquid Biopsy Truth: What $40 Billion in Cancer Screening Really Buys Us A masterful The New Yorker investigation by Siddhartha Mukherjee reveals why finding cancer early isn't what we think it is. Here's what longevity clinics don't tell you... 🧵

This is the primary figure for which I have yet to hear a compelling explanation from those who deny a causal relationship between LDL-c/ApoB and atherosclerosis. … this is not even mentioning how consistently it fits with other lines of evidence.

Dear Neurology Residents Starting in the ED Next Month, You will frequently encounter “?GBS” or “GBS rule out” consults. Please remember to carry your reflex hammer, save this post for future reference, and read the open-access review that I share ⬇️. 🤓 Since you won’t have

🧵 “ANA Positive ≠ Lupus: The Art of Interpreting Autoantibodies” ANA positivity is one of the most misunderstood findings in medicine. Here’s how to approach an ANA report systematically, clinically, and with confidence. 👇 #Rheumatology #ANA #Autoimmunity #MedEd Dr. Akhil 🇮🇳

Unsurprisingly Cyril Zakka, MD says it better than I could. These are the exact concerns I have about the way we are integrating LLMs into clinical care. It *might* not matter, but we are all participating in an educational Pascal's wager right now. A 🧵🔽

Amazing review of under-appreciated physiology, with important practical implications for anyone managing ADHF 👇

Viewpoint: Prostate cancer screening is shifting toward a more beneficial and less harmful approach by using MRI-targeted strategies, which reduce unnecessary biopsies and overdiagnosis. ja.ma/45rVOSb Ivo Schoots

📉Lower LDL-C for longer is better. The NLA’s new guidance simplifies LDL-C management for adults — helping clinicians & patients improve evidence-based measurement and treatment of LDL-C. Read the guidelines & recommendations: lipidjournal.com/article/S1933-…. Beth Jackson Christie Ballantyne

Is this the end of rivaroxaban for acute VTE? Lana Castellucci presenting the COBBRA trial - 1st RCT comparing apixaban to riva over 3 months. 56% reduction in bleeding risk with apixaban. A safer Rx with the same efficacy. #ISTH2025

🎺UBC TI Therapeutics Letter 156: Antidepressant withdrawal syndrome – Update 👉 ti.ubc.ca/letter156 Antidepressants can be helpful for some people; but starting or stopping requires care Knowing about types of possible withdrawal problems helps prescribers guide patients