Published today in Cell, research by Arlotta Lab shows that human brain organoids replicate many important cellular and molecular events of the developing human cortex, suggesting they can be used to study human brain development in health and disease 🧠 cell.com/cell/fulltext/…

Recapitulation of mouse embryonic development from stem cells in vitro seems interesting to study early mammalian development! nature.com/articles/d4158…

Scientists looked at over 250 candidate treatment strategies for reversing dysregulated gene expression in Alzheimer's disease. Guess which one won? Exercise. nature.com/articles/s4159…

Hot on the heels of our adult human cell atlas, we present the emergence of human brain cell types during the critical first trimester! Fabulous work led by Emelie Braun and Miri Danan Gotthold with many collaborators. Tweetorial 🧵below 👇🏼with links to preprint, data, and code. x.com/EmelieBraun1/s…

Exercise causes muscles to act like a sponge and take up kynurenine, preventing its conversion to a neurotoxic agent implicated in depression. A meta-analysis of 25 randomized controlled trials found aerobic exercise reduced depressive symptoms in people with depression.

Kicking off the Annual Sellgren Lab Meeting'22 at KI with fun discussions and current/future perspectives related to our research for the upcoming year⚡️🎉

In this N&V, GonçaloCasteloBranco and Karl Carlström discuss the implications of a study that unveils a previously unknown role for oligodendrocytes in Alzheimer’s disease, involving the protein APOE4 and changes in cholesterol metabolism. go.nature.com/3EALwkF

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This week we have Asimenia Gkogka and Marja Koskuvi representing our lab at Lund Stem Cell Center's conference. If you're interested in our ongoing projects with brain organoids🧠, feel free to chat with us at posters #81 and #84 today and tomorrow. #LundStem2023

"Alysson Muotri launched brain organoids into outer space and found that microgravity enriches our understanding of brain development and disease." Spectrum has previously covered Moutri’s work: bit.ly/2M8Ho1p. bit.ly/3CGF0r2

OPCs and microglia engulf synapses head-to-head in new forebrain organoid model. Arwen1509 Asimenia Gkogka Susmita Malwade Martin Schalling Karolinska Institutet Oligodendrocyte precursor cells engulf synapses in a model of the developing human forebrain biorxiv.org/content/10.110…

#ECNP2023 It's a wrap! 🧠 We enjoyed 3 days of inspiring talks, networking, and fun activities in Barcelona! A shout out to Asimenia Gkogka,Marja Koskuvi Susmita Malwade, Martin L, Funda Orhan, and Jingjing for their wonderful posters and we look forward to exciting upcoming research!

Inhibiting KATs and the production of endogenous KYNA rescues excessive synaptic pruning in forebrain organoids #KynurenicAcid. New pre-print by Orhan et al. Susmita Malwade Arwen1509 Asimenia Gkogka Marja Koskuvi Sophie Erhardt Koistinaho Lab Šárka Lehtonen biorxiv.org/content/10.110…

It was a pleasure attending StratNeuro and interacting with so many researchers in the field!

Grateful for the opportunity to meet and present to such impactful scientists today! SellgrenLab

Actual representation of me today

If you're at the CSHL meeting and want to know more about human OPCs in the developing brain, don’t miss Asimenia Gkogka's talk on our latest findings today in Session 6, starting at 14:45! #cshl2024brain

Excited to share that I presented my research at the Cold Spring Harbor Laboratory meeting in NY on Development & 3D modeling of the human brain🧠! Honored to be among 300+ participants and share the stage with leading researchers 🎤. Looking forward to future collaborations! #CSHL2024Brain #StemCells

New issue in Am J Psych Amer Psychiatric Pub focusing on schizophrenia. We report a decrease in synapse loss in schizophrenia-derived organoids by inhibiting KAT enzymes Kynexis psychiatryonline.org/doi/10.1176/ap…

After 3 days, 4 airports, and 5 cities (thanks, flight cancellations!), nothing could stop me from making it to #GLIA2025 in Marseille 😂✈️ If you’re here too, swing by my poster (T11-114-C) today to chat OPCs, neurodevelopment, and stem cell models 🧫 Let’s connect!