I wrote down my rules on how to Science. I hope you find it useful!

🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today nature Strand-resolved mutagenicity of DNA damage and repair nature.com/articles/s4158… Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]

A #ResearchHighlight discusses "Tandem repeat variation of human centromeres" go.nature.com/3wii3ea - based on a recent @nature paper by Glennis Logsdon x.com/glennis_logsdo…

The human chromosomes are numbered incorrectly (The fourth in an irregular series of threads about #Bioinformatics.) As most people know, 22 of our chromosomes are numbered from longest to shortest, plus we have X and Y... 1/6

We use FinRegistry (8,000+ features) + deep-learning to predict 1-year mortality for the entire Finnish population (AUC=0.95)! Derive a powerful digital marker of aging And show predictions are subject to geographical and socio-economic unfairness

Antoni Gaudí was born 172 years ago today. He's one of the most beloved architects in the world, and that makes sense — his style is utterly unique. But Gaudí only designed 17 buildings...

Methods and applications of genome-wide profiling of DNA damage and rare mutations go.nature.com/4chbjNb #Review by Gerd Pfeifer & Van Andel Institute (VAI) Free to read here: rdcu.be/dLQhe

📢Online now! 📰Splicing-specific transcriptome-wide association uncovers genetic mechanisms for #schizophrenia 🧑‍🤝‍🧑Grace Xiao Bogdan Pasaniuc & colleagues cell.com/ajhg/fulltext/…

Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with Jonathan Weissman's Lab's Edwin Neumann & Tessa Bertozzi shows deep silencing of brain PrP Paper: science.org/doi/10.1126/sc… Blog: cureffi.org/2024/06/27/int…

Long associated with aging, senescent cells can promote health and have physiological roles. Learn more in a new #SciencePerspective: scim.ag/7uC

According to biologists, the function of zebras' stripes is to ward off insects. Based on that idea, a team of scientists painted zebra stripes on cows. This reduced the number of biting flies on the cows by more than 50%. Applied evolutionary biology! stevestewartwilliams.com/p/how-the-zebr…

🚨Free for 1 month: Revealing gene function with statistical inference at single-cell resolution go.nature.com/4eMji6A #Review by Cole Trapnell UW Genome Sciences

Calico cats are not a breed of cats, but they have a distinctive orange and black color pattern linked to the X chromosome and its inactivation pattern! We think that’s just purrr-fect. 😺

Stem cell pathway for blood cells

Today in Science Magazine, we report how a bacteria has evolved into a major human pathogen over the last 200 years. Read on, this is going to be an adventurous ride 1/n! science.org/doi/10.1126/sc…

🚨 Paper Alert! In Nature Methods, a Vienna BioCenter-wide collab with Perutz PI Stefan L Ameres, Julius Brennecke, Ulrich Elling & Alexander Stark has developed ORFtag - a groundbreaking method to systematically investigate proteins and their functions ➡️ tinyurl.com/8khp6bdp

Lymphocytes as a living drug for cancer science.org/doi/10.1126/sc…

In this week's blog post is I write about genetic modifiers, highlighting some recent and past examples related to Alzheimer's disease, APOL1-mediated kidney disease, Huntington's disease and sickle cell disease. gwasstories.com/p/natures-undo…

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… Gustavo França

Thanks, Safia Danovi, for a lovely "Research Highlight" in Nature Genetics about our "understanding X chromosome loss"!! 🧬🧬🧬 nature.com/articles/s4158…