✨Please joins us for the Biophysical Society MGO Subgroup sponsored webinar on Tue Aug 1st at 12pm ET for two great talks!✨ Multiscale Genome Organisation Bin Zhang Kazuhiro Maeshima 👇 Register at tinyurl.com/3pvytb2s

Read my latest #research [authors.elsevier.com/c/1hUDz3PA3sV0…] on #Chromatin, #Genome, #Simulation, #HiC, #reconstruction, #Mesoscale, #Genes, #Modeling, #Methods, #Multiscale, published with Co Conscious Birth in Elsevier Tamar schlick

Nucleosome repositioning in chronic lymphocytic leukaemia dlvr.it/Swqhgq

What to expect from the next release of Alphafold deepmind.google/discover/blog/…

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors dlvr.it/T1PmjT

Interested in the genome and attending #bps24? Join the MGO subroup and attend our symposium on Saturday which includes talks by Mario Halic HalicLab Emma Morrison Emma Morrison Alexey Shaytan Alexey Shaytan Remo Rohs Remo Rohs biophysics.org/store/products…

POLE variants promote genome-wide mutations in polypurine tracts - check out our paper by Daria Ostroverkhova in collaboration with Polina Shcherbakova's lab cell.com/cell-reports/f…

Congratulations, Bing-Rui!

Happy to share the publication of our paper in nature Conformational ensembles of the human intrinsically disordered proteome Work led by Giulio Tesei and Anna Ida🕊. I'll post more later, but for now here is a link: nature.com/articles/s4158… and a short movie about the work

Our work on the identification of new pioneer transcription factors is out, in collaboration with Yunhui Peng David Landsman Teif Lab elifesciences.org/articles/88936

Happy to share this just out in eLife (full text to follow soon) 👇This was a really great collaboration with EpiCypher, Inc. and very excited about the results! CU Anschutz Medical Campus Department of Biochemistry and Molecular Biology

Excited to present the first ageing clock based on nucleosomics of cell-free DNA (cfDNA)! onlinelibrary.wiley.com/doi/10.1111/ac… ✅ Nucleosome repeat length increases with age ✅ Can predict age with ~3 year precision Congrats to Mariya Shtumpf, nrnflowers, Mila Bikova, Hulkar_M, Lumi Ruje!

Check out our new study of nucleosome positioning using deep residual networks biorxiv.org/content/10.110…

Can next-generation pathogenicity predictors, like #AlphaMissense and VARITY, be effectively applied to cancer? Check out our study on a carefully designed experimental benchmark: biorxiv.org/content/10.110…

Check out a short paper by Daria Ostroverkhova and Yiru Sheng on pathogenicity predictors and their applicability to cancer: sciencedirect.com/science/articl…

Nice to see our manuscript on bacterial histone HBb from Bdellovibrio online: academic.oup.com/nar/advance-ar… Different from eukaryotic/archaeal histones, HBb binds and bends DNA as dimer. With Birte Hernandez Alvarez, Vikram Alva , Yimin Hu, @SammyBoterhammy , @MPI_Bio , Leiden Science

Journal cover Nucleic Acids Res highlights our new method, RNAscape, for mapping base pairing and tertiary interactions in RNA structure: academic.oup.com/nar/article/52…. Same NAR issue features our new deep learning method to predict DNA shape: academic.oup.com/nar/article/52… USC Dornsife College of Letters, Arts & Sciences USC Research

Our new nucleosome positioning prediction method has been published. If you want to use it or see which nucleosomal features are deemed important: academic.oup.com/nar/advance-ar…

Happy holidays, chromatiniers! Our new paper on histone cancer mutations and links to DNA repair: biorxiv.org/content/10.110…

Our study, in collaboration with Maria Aristizabal’s lab, predicted several histone cancer driver mutations with long-range allosteric effects and confirmed them experimentally: sciencedirect.com/science/articl…