Single-cell sequencing reveals multiple transcriptomic cell states adopted by human #microglia xenografted into #Alzheimer ’s disease model mice

MINDlab @DeStrooper Nicola Fattorelli Anna Martínez UAntwerpen VIB Center for Molecular Neurology VIB-KU Leuven Center for Brain & Disease Research VIB KU Leuven…

A team led by Prof Bart De Strooper (UK DRI at UCL & VIB-KU Leuven Center for Brain & Disease Research) has transplanted human microglia into mouse brains to study how the cells respond to amyloid plaques in #Alzheimers 🧠

The findings could have implications for future treatments👉buff.ly/3TT7BCI

New research is crucial to understand & treat Alzheimer's, which is predicted to triple by 2050. A recent study led by De Strooper Lab (@CBD_VIB) and MINDlab (@CMN_VIB) sheds light on the role of microglia, immune cells in the brain, in Alzheimer's.👉 vibbio.tech/49c6pyL

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology nature.com/articles/s4159…

So happy to see our latest work published today in Nature Neuroscience 🥳 terrific team effort and loads of fun with shared first authors MINDlab and Anna Martínez at De Strooper Lab. Microglia enthusiasts, let's take a short journey through the paper 🧵⬇️ go.nature.com/4av0PZd

🚨it’s out!! Check our latest work in Nature Neuroscience. What a privilege to have worked with MINDlab and Nicola Fattorelli and the amazing colleagues at the De Strooper Lab, MancusoLab, VIB-KU Leuven Center for Brain & Disease Research , VIB Center for Molecular Neurology , UK Dementia Research Institute

I might be biased as besides being fantastic scientists, these people are awesome humans, but I’m so absolutely proud of the work done by Anna Martínez Nicola Fattorelli MINDlab 🧠 PS. Still a neuron lover over here, but ok, microglia is cool too 😎 #ADPD2024

Pleasure to have Anna Martínez showing her work ICVS

PhD Position available NIM lab
We offer a fully funded PhD position to study the role of T cells in Autism spectrum disorders. If you want to work in a dynamic and international environment VIB Center for Molecular Neurology in the beautiful city APPLY before 10th January

jobs.apeng.uantwerpen.be/psc/apeng/EMPL…

🎙Selected talks at #PBIC23 add to the discussion: Sebastiaan De Schepper on how gut macrophages impact Parkinson's; Veerle Baekelandt on a key gene in the disease & it's role in the peripheral immune system; Anna Martinez Muriana on insights into human myeloid ontogeny.

💡Exciting news in #Alzheimer ’s research! De Strooper Lab and VIB-KU Leuven Center for Brain & Disease Research published a new paper in Science Magazine uncovering the cause of brain cell death in the disease. Learn more: vibbio.tech/44RBTYP
UK Dementia Research Institute KU Leuven

📢PhD position alert📢
We are hiring a PhD student to study Early-Life Pathological Imprinting of Alzheimer's Disease via Lifestyle. 🧠🧑🏾‍🎓👩🏾‍🎓🔬Exciting research, Fun team, Fun city (Amsterdam🇳🇱) Apply now👇🏾
vacatures.knaw.nl/job/PhD-positi…

Feeling the post- #NIM2023 depression? Come join us at the end of September in Venice and let’s discuss neuroimmunology in the context of neurodegeneration! How do neurons, astrocytes, macrophages and microglia at parenchyma and borders contribute to cellular vulnerability?

An MCH-mediated homeostatic mechanism counteracts the increased excitatory drive to CA1 neurons and altered #sleep in Alzheimer's disease model mice, but this mechanism fails in older mice

New from Sara Cesariny Calafate Lab of Synapse Biology De Strooper Lab and colleagues

Thanks to @HenekaMichael for giving us the chance to show our latest data on how human microglia respond in Alzheimer’s disease! And thank you all for the fantastic discussion! VIB VIB Center for Molecular Neurology UAntwerpen

☕️ Fresh out of the press in Neuron!!

Happy to share our manuscript “Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: reconciling controversy or fueling the debate?” Salta Lab NIN

cell.com/neuron/fulltex…

🧵1/n

Prof. Emanuela Pasciuto is hiring a postdoc for her brand new lab. jobs.vib.be/j/55076/postdo…

Human microglia respond differently to amyloid than do mouse microglia. The former adopt antigen-presenting, cytokine-, and interferon-based responses, while the latter mainly assume the DAM phenotype. #alzheimersdisease KU Leuven Boston Children's ow.ly/eCBI50LnuVn

So cool to see our research featured on Alzforum!! Take a look at the article below for a nice summary of the in vitro study from beth stevens and our xenografts work with MINDlab Anna Martínez De Strooper Lab 🧠🧫🐁

Multi-pronged is our new favorite word! AD genetics is complex, and so is human microglia reaction to amyloid. Check out our latest pre-print 🧠🐁⬇️ biorxiv.org/content/early/… Massive collaborative work and fun with MINDlab Anna Martínez De Strooper Lab VIB-KU Leuven Center for Brain & Disease Research