(1/n) 2023 begins with new hopes & dreams. Restarting our #FrugalScience global adventure this year with an invitation to global cohort of problem solvers. Here is invitation for global community to engage - come solve hard problems with us with a little bit of play.

Handmade time-lapse of zebrafish development. Credit to Andro MR. #ZebrafishZunday

Sonification in science by Los Angeles Times - including our collaboration on sounds of protein folding with Martin Gruebele, Symbolic Sound & Stephen Marshall 🎼🤓Chemistry at Illinois Illinois Music Research & Innovation at Illinois University of Illinois

I am sorry

ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY. Can we do structural biology with an optical microscope? Yes! Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out today in nature! nature.com/articles/s4158… Jungmann Lab Max Planck Institute of Biochemistry (MPIB)

Undergrad TAs along with school kids (9th to 12th standard) managed to capture this beautiful time lapse video using a mobile camera and a Foldscope (Foldscope) at Ashoka University during the Lodha Genius Programme programme. Proud moment for me as an Instructor! #LGP #LifeSciences (1/n)

Every government & university science administrator should get a framed copy of these words of max perutz on the first day on the job.

Our ability to design biological systems is improving rapidly. In 40 years, the field went from modeling three genes in phage to building synthetic gene circuits with 76,000 bases of DNA. A brief history of genetic design, told in 7 experiments. Read: letter.asimov.com/p/design-histo…

Great to see the people at DeepMind behind AlphaFold get the recognition of a Lasker Award! But award committees, don’t forget that David Baker at UW has been pushing this field forward for years, all in an open academic setting.

You desk rejected their seminal paper.

1/ 🤖 New paper hot off the press 🐜 Automated behavioural analysis using machine learning is great, but still needs lots of effort to curate training data. What if a computer could generate that data for you? Say hello to replicAnt nature.com/articles/s4146… #OpenSource

Nobel Laureate Peter Ratcliffe on finding your own scientific problem. podcasts.apple.com/us/podcast/nig…

Every entrepreneur in science and technology who aims to develop products should attend this course. This is a gem 💎

Our first paper is out in Cell! Led by Rohith Rajasekaran, we present a programmable reaction-diffusion system that generates synthetic protein waves, oscillations, and patterns for spatiotemporal circuit design and FM data-encoding in human cells. authors.elsevier.com/a/1iN8ZL7PXmeeN

I loved this:

Important reading nature.com/articles/s4155…

NEW PAPER: Ever wondered why insects fly in all sorts of crazy patterns around lights at night? So did we! We set about recording flying insects to work out what's going on. I'll summarise what we found in this 🧵. Spoiler: We don't think they confuse lights with the moon.

Real science: 1. Is not correlated with the amount of funding 2. Progresses slowly, usually taking many years 3. Leads to more questions than it answers 4. Advances when we disengage & in improvisational discussions 5. Is too important a thing to be done in a non-playful way

Amazing what open hardware enables !

Are you ready to dive into microscopical wonders? HHMI | Janelia's #BeautifulBiology project is live! 300 pages of content featuring over 425 images and videos with explanatory texts to give scientific context. Zoom into a gigantic world of infinitely small beauty!