Check out our new work to read about one of the most surprising (and amazing) results of my career: Plasmids are governed by a universal scaling law that links copy number and size across phylogenetic boundaries. A real tour de force by Paula Ramiro, Nacho de Quinto Cáceres and J_Gamma! 👇

Also, don't forget to check this amazing paper from Lingchong You lab, where they independently discovered similar plasmid scaling laws! It's so cool when teams from different parts of the world simultaneously discover results that support each other! biorxiv.org/cgi/content/sh…

Quite excited about the latest "Universal rules govern plasmid copy number", with my new group: Paula Ramiro Nacho de Quinto Cáceres & Jerónimo Rodríguez-Beltrán ! Have you given it a look yet? Check also the supporting work by Lingchong You & Co.

Meet The Shielded Plasmid🛡️🧬 Our new nature paper reveals how plasmids outsmart bacterial defenses during conjugation. It's all about being in the right place at the right time! The positioning of anti-defense genes boosts transfer efficiency🧵(1/7) nature.com/articles/s4158…

Finally out after peer review. The first SuperIntegron-less Vibrio cholerae... and it is virtually identical to the WT! doi.org/10.1093/nar/gk…

Checkout the last work from the lab!! Really important work for the field of integrons! 👏🏻

In our new study, we show that plasmid carriage can affect the frequency of microindel mutations in their host: doi.org/10.1016/j.plas… With: Mikkel Liljegren, @Paal_Johnsen & Klaus Harms

Finally out after peer review, our update on the integron model showing that translation rates of cassettes in first position influence the phenotypes conferred by others downstream. Great effort by André Carvalho nature.com/articles/s4146…

For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species. We are thrilled to see this work now published in Nature Microbiology after thorough peer review! nature.com/articles/s4156…

Exciting times! Our latest preprint is now live 🤩! I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n biorxiv.org/content/10.110…

🚨New preprint!! How do antibiotic-resistant bacteria grow in the human gut microbiome, even without antibiotics? 🤔 We reveal strain-specific ecological interactions that shape their growth within microbial communities. 🧵👇 1/5 biorxiv.org/content/10.110…

Félicitations à nos lauréats du Prix Agnes Ullmann ! Zeynep Baharoglu explore l’impact des modifications de l’ARN sur la résistance aux antibiotiques. Thomas Rolland contribue dans le domaine la génomique des troubles neurodéveloppementaux. Bravo pour à eux pour ces travaux !

Our paper on 🦠queuosine 34 modification of tRNA tyrosine and antibiotic response is finally out in its final form in eLife - the journal ... and quite different from the preprint version. Many thanks to reviewers, editors and kudos to all authors🙏 elifesciences.org/articles/96317

"The pathway to resolve dimeric forms distinguishes plasmids from megaplasmids in Enterobacteriaceae | Nucleic Acids Research | Oxford Academic" academic.oup.com/nar/article/53…

With José R Penadés, we challenged AI co-scientist Google AI to generate hypotheses. In just 2 days, it recapitulated our unpublished, experimentally confirmed mechanism for how cf-PICIs spread between bacterial species! 🤯 Imperial College London Fleming Initiative tinyurl.com/3byyaeh2

💊🔬 The environment changes everything… even antibiotic resistance! In our last work, we explore how oxygen shapes resistance genes (like NMD-1 or VIM-7) from a #OneHealth perspective🌍 Amalia Alberto.HCA Nicolas Kieffer, PhD Jose A Escudero More info ➡️ sciencedirect.com/science/articl…

With a bit of a lag for X... 🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 Short 🧵 science.org/doi/10.1126/sc…