Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…

TDP43 mislocalization and aggregation are the hallmarks of several neurodegenerative diseases. Especially #ALS, #FTD. We recapitulate the initial pathogenic events in iPSC-derived #neurons and show that TDP43 accumulates within autophagosomes and lysosomes. #insitu #cryoET 1/

The big one is out 🎉 So over the moon to see our latest work with Steph Vassilopoulos published in Science Magazine. Check out how we reveal the unique architecture of clathrin-coated pits and endocytosis at the axon initial segment: science.org/doi/10.1126/sc…

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…

biorxiv.org/content/10.110…

We find members of the TMC family of putative #mechanosensors at the tips of #intestinal #microvilli! Bechara Kachar Modeling Angela Ballesteros and molecular dynamics simulations Sotomayor Lab at OSU suggest they may be ion channels and/or lipid scramblases, like TMC1 at #stereocilia tips!

Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…