We're honored to once again been named to U.S. News & World Report Best Children’s Hospitals Honor Roll for the 2024-25 rankings. We ranked No. 1 in three specialties, and we placed in the top 10 for all 10 ranked specialties - cincinnatichildrens.org/news/release/2…

Excited to join the Editorial Board of The Journal of Pain ! sciencedirect.com/journal/the-jo…

New paper by Jorge Palop's lab Cell Reports we collaborated. We report a #MachineLearning platform for unbiased & sensitive behavioral analysis of #Alzheimers mice & protection from AD behavioral alterations by genetic #fibrin inhibition. cell.com/cell-reports/f…

Our latest work in Nature Biotechnology describing a new molecule with potential for non-opioid pain relief. We developed a prodrug that releases monomethyl fumarate at sites of oxidative stress, relieving pain in models of neuropathy and osteoarthritis nature.com/articles/s4158…

Always exciting to kick off the ASSURE program application season. Know of any college students in #StLouis who are looking for an introduction to research? ASSURE is specifically intended for students who have not had easy access to similar opportunities. #ASSURE2025

Recording from hDRG on this chilly snow day! #neuroscience #pain #snow

Stellar work!

The Alles Lab is now on Blue Sky! bsky.app/profile/allesl…

Thrilled to announce that the Alles Lab & family are moving to Cincinnati! We will join the Dept of Anesthesiology Cincinnati Children's next year. We look forward to continuing our work on molecular/cellular mechanisms of #chronicpain & starting exciting new projects soon 🎉🥂

If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15 When mitochondria cannot flux energy properly, the cell

Our latest work in collaboration with the June Bryan de la Pena lab on the effects of neuropathic pain drug gabapentin on human DRG neurons is now online!! Spoiler alert: interesting donor-specific actions! #PainResearch #humanDRG biorxiv.org/content/10.110…

Looks like a great opportunity. If any prospective postdocs are interested in applying for translational medicine project funding to work in my lab in 2026, please reach out! #ChronicPain

Looks like all members of the Alles Lab will be moving! Most of us to Cincy & one of us for a great postdoc opportunity elsewhere. Excited to see great things from each of you! 💪👩‍🔬🔬 #PainResearch

McIlvried, John Del Rosario, Rob Gereau et al. WashU Pain Center show that mechanisms of adaptive plasticity are engaged in mouse and human sensory neurons after sustained depolarization. hubs.la/Q02_YmnR0 #CellularPhysiology #MolecularPhysiology

It is with great pride that I share the bulk of thesis work from my first PhD Candidate Aleyah Esther Goins on neuroimmune mechanisms of chronic back pain! This is a new direction for the lab led by Aleyah's sheer curiosity and drive to understand #chronicpain biorxiv.org/content/10.110…

Great way to kick off 2025 with a visit to see my buddy & fellow human tissue enthusiast Mike Hildebrand at Carleton University Research in my hometown 🇨🇦 #painresearch

I am pleased to share Oluwaseun (Dr. Adewale Fadaka) newest report on a novel neuroimmune mechanism of inflammatory muscle pain in neonates. The intersection of endocrine signaling and neuroimmune communication ... sciencedirect.com/science/articl…

The Chamessian Lab WashU Pain Center is recruiting a #postdoctoral research associate to build on the foundational findings from our recent preprint showing that ion channels can be degraded by PROTACs. #TPD #PROTAC #drugdiscovery #pain #ionchannels. We're a fun group with an

Excited to get things going here Cincinnati Children's!!

🎙️ New #Podcast: Neuroverse speaks with Professor Sascha Alles, Alles Lab about the complex world of chronic pain. Learn how pain signals are generated & processed, what drives #chronicpain, & how new technologies are transforming our understanding. 🔗buff.ly/5gYoptR