Happy to release this one to the world. Another great collaboration with Lucy Palmer initiated by Guilherme Testa Silva. My first foray into human neurons! biorxiv.org/content/10.110…

New data revealing that acetylcholine stimulates recurrent excitation in networks of PT pyramidal neurons in the mouse prelimbic cortex.

"Cholinergic activation of corticofugal circuits in the adult mouse prefrontal cortex" Acetylcholine enhances excitatory synaptic transmission in layer 5 pyramidal tract neurons of prefrontal cortex, promoting output to the thalamus and brainstem. doi.org/10.1523/JNEURO…