Bonjour mes amis! Do you like bioinformatics, omics, neuroimmunology, and cheese? Open postdoc (or potential PhD) position in the Merkler lab in Geneva, Switzerland. Come enjoy the great science, high quality of life, and Swiss salary 🤓 DM for more info euraxess.ec.europa.eu/jobs/569913

"Unsupervised clustering resulted in 12 clusters, 7 of which resembled a whale and potentially represent terminally drowned T cells" 🥸 @d_shlesinger

Sharing super special collab work 🙏profiling B cells in the CNS w/ infection and autoimmunity. Murine ASCs were expanded & class-switched following ic viral infection and proliferated/expanded after local induction of neo-self antigen 🧠 Similar phenotypes in CSF of MS patients

Happy to share our recent manuscript from LSSI Reddy has been published in Cell! Great work by Joseph Taft & Cédric R Weber et al. Moving towards predicting immune escape of future viral variants🤓

Grateful to share I’ll join Center for Translational Immunology NL as a TT Assistant Prof. So much love to all who have helped me follow my curiosity both professionally🧬and personally🏳️‍🌈 Excited to keep exploring how computational, synthetic and systems immunology can be translated to the clinic

Riding the good news wave - honored to share I've been awarded an SNSF #Ambizione Grant to study the interplay between vaccination and original antigenic sin. Please DM if you know anyone interested in an experimental or computational immunology PhD in a fun Dutch Swiss collab!

Sharing our recent hodgepodge paper in Nature Genes & Immunity if anyone wants references & public scSeq datasets. Includes transcriptomes + repertoires from Tfh/Tfr/CD8 T cells (following infection/CNS neuropathology) + B/T cells from EAE (rMOG/MOG35-55)🍾nature.com/articles/s4143…

One of my scientific mentors and role models said I need to update my pinned tweet with some more recent research. I agreed and updated w/ a grindr screenshot 🤠

Happy to support monotreme awareness with our single-cell immune repertoire simulation tool Echidna now Bioinformatics Advances. Integrated SC repertoires & transcriptomes. One fun case was simulating clonality & B cell evolution on spatial images for pipeline development for future projects

We are hiring two computational immunology PhD students at UMC Utrecht International in the Netherlands working on adaptive immunity in my group and in the group of Femke van Wijk. Please spread the word and DM me for more info!🧬 werkenbijumcutrecht.nl/vacatures/wete…

How do #Bcells contribute to chronic inflammatory #CNS diseases? Read it in #ActaNeuropathologica by Alex Yermanos & Geneva Centre for Inflammation Research Doron Merkler Merkler lab! 👉article: bit.ly/3wOqHxj 👉summary: bit.ly/3jgmS0Z #Viralinfection #Autoimmunity #MultipleSclerosis

I wanted to highlight some of our 2022 work published in PNAS and the European Journal of Immunology in light of a new publication that should be released in a few days 🍾 - thanks again to all collaborators! - particularly Oxenius Lab LSSI Reddy linkedin.com/posts/alexyerm…

We are already sending out interview invites in the next few days for the two computational immunology #PhD positions at Center for Translational Immunology in case you haven't submitted an application yet but wanted to 🧬🍾

Sharing our new pub in iScience journal relating Bcell repertoires & mAb specificity! Previously we saw ~35% of expanded IgG plasma cells were immunogen-specific. Here we show a similar % using a therapeutic protein (w/ self-homology) in young but not old mice doi.org/10.1016/j.isci…

Happy to sharing a nice collab now out in Cell Reports lead by @FGrabnitz & Oxenius Lab investigating how asymmetric cell division influences T cell development! cell.com/cell-reports/p…

Happy to share our review summarising the extremely recent explosion of protein language models (PLMs) that are being applied to adaptive immune receptors. Thanks to everyone involved and sorry if we missed some models - they are being released so quickly! arxiv.org/abs/2402.03823