Periodic Labs and the U.S. Department of Energy are collaborating to accelerate scientific discovery. The 17 US national labs have driven decades of scientific advances. Now, we’re rethinking a scaling-era of science by connecting AI to physical experiments.

comment “vibecon” for a chance to win a free ticket

At Tahoe, I recorded this video to wish you a Merry Christmas. It takes thousands - sometimes millions - of years for rocks and mountains to form. It takes hundreds of years for pine trees to grow tall and strong. Yet it takes just one night for inches of snow to fall, creating

When I proposed building generative models for protein design for my PhD ~8 years ago, the idea was seen as impractical and a toy problem. The models were hilariously bad at the start, producing noodle-like structures and incoherent sequences. I just kept working on it because I

On the first day of the new year, I thought about a question people often ask me: Do you like working in AI investing? My answer is simple. I feel like a kid walking along a beach, picking up stones. Every now and then, I find one that’s beautiful, and it makes me genuinely

After 15 wonderful years General Catalyst I am moving on to new adventures. The best days for GC are ahead! Super grateful to every single one of my teammates that I had the fortune to work with over the years. I learned a lot. Very thankful to our limited partners too for their

Corgi is coming out of stealth with $108M raised to build the future of financial infrastructure. A lot of the GDP flows through highly regulated financial entities that haven't been meaningfully changed in decades. To fix this, we're starting in insurance.

I’ve been telling people this a lot today: I enjoy so much working with people who care about what they are building and craftsmanship. It is a privilege to have a chance to work on something I’m passionate about, beyond making a living. I cherish it and don’t take it for

2026 AI founders, here’s your opportunity: Assume models are 10× better and cheaper at (1) coding, (2) reasoning, and (3) multimodality. What should you build that fully leverages these capabilities—in ways that compound your advantage instead of making you replaceable?

If most people are talking about an AI bubble, then there is probably no AI bubble.

Before there was a tiger in the mountains, the monkey thought he was king—because he believed he was smart enough. This is similar to many AI companies today. Before the company that truly disrupts and kills you shows up, you may taste a bit of early success. But without deep

In the market - whether public or private - there are really only two kinds of great companies: white horses and black horses. White horses are Beta. Think NVIDIA in 2023, Google in 2025, Micron Technology today, or the hot vertical AI unicorns everyone agrees on in the private

Who is still using Perplexity ? For what?

It started as "idea to app". It's becoming "idea to everything". Stay tuned 👀

Announcing DreamDojo: our open-source, interactive world model that takes robot motor controls and generates the future in pixels. No engine, no meshes, no hand-authored dynamics. It's Simulation 2.0. Time for robotics to take the bitter lesson pill. Real-world robot learning is

We trained a humanoid with 22-DoF dexterous hands to assemble model cars, operate syringes, sort poker cards, fold/roll shirts, all learned primarily from 20,000+ hours of egocentric human video with no robot in the loop. Humans are the most scalable embodiment on the planet. We

There's a hidden tax on every knowledge worker in the world, and nobody talks about it: The design tax. You're a strategist, a sales lead, a marketer. You were hired for what you know. But every meeting, every pitch, every proposal expects you to show up with something that

Re-introducing...Bond, your AI Chief of Staff. You worked 10 hours yesterday. Maybe 2 of them actually mattered. The rest? Standups, Slack threads, status updates, triaging emails. Executives don't need to work harder. They need Bond 👉 bondapp.io

Congrats to my girlfriend Yusan and everyone at Mirror Mirror! They rolled out a marketplace connecting fashion models to brands. They then custom generate content. Models want control over the use of their likeness and people like seeing real models (not just fake AI people)!