🧠The synapse density rapidly increases post-birth👶, reaches its maximum during infancy, at which stage it is double the amount that will be observed in adulthood. 📕Conel, JL. The postnatal development of the human cerebral cortex. Cambridge, MA: Harvard University Press; 1975

Why Drug Developers Have a Growing Interest in Targeting Mitochondria podbean.com/ew/pb-7qnmn-15… Listen and learn...

Must-read review article

Let me highlight and contextualize our new study that will undoubtedly be controversial: ‘Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP’. Long thread 👇🏻 1/ biorxiv.org/content/10.110…

📣REGISTRATION is open Please follow the link sfb1218.uni-koeln.de/mito-crc-event… #mito #crc1218 MPI for Biology of Ageing CECAD Cologne

First half marathon done! Great time (for me) and no rain!

'Balancing neuronal activity to fight neurodevelopmental disorders' 'Spotlight' commentary by Stephanie Le, Carmen Menacho & Alessandro Prigione Alessandro Prigione cell.com/trends/neurosc… discussing Rylaarsdam et al., Nature Communications, Alicia Guemez-Gamboa nature.com/articles/s4146…

Very happy to share our new article of the interaction of mitochondria, innate immunity and viral infections and the relevance for brain &liver disease. Impressive work by Yilin Kang. Thanks Jussi Hepojoki Olli_Vapalahti and all collabs! University of Helsinki Anu Suomalainen-Wartiovaara Lab rdcu.be/dDx2G

Wonderful opportunity! A great lab in a new exciting institute in a great city. Apply!

Postdoc positions in pancreas development & stem cells in the Spagnoli Lab Spagnoli Lab Come join us as a #postdoc to lead a new exciting #T1D Grand Challenge-funded research program on engineering #stem cell-derived islets jobrxiv.org/job/kings-coll… #d... jobrxiv.org/job/kings-coll…

How do axons maintain functional #mitochondria? Happy to share our last #CLUH story. #ScienceAdvancesResearch science.org/doi/10.1126/sc…

Researchers at Max Delbrück Center and Heinrich-Heine-Universität Düsseldorf have identified a gene that affects mitochondria in an #organoid model of #Huntington’s disease. The gene may contribute to brain abnormalities much earlier than previously thought. Nature Communications Metzger Lab Alessandro Prigione mdc-berlin.de/news/news/new-…

Beautiful run this morning for the Kastelo charity run. Thanks to the SSIEM2024 organizers! SSIEM 2024 Annual Symposium

Next up in the modelling IEM session, Dr Alessandro Prigione discusses developing brain organoid models for the study of #mitodisease. In addition to developing robust models, he has begun working on drug repurposing #excitingstuff #raredisease #SSIEM2024 (not brains in jars)