Fascinating presentation by prof. Sophie Van Linthout on pathological mechanosensing. ❗️Extracellular matrix and mechanical triggers in the diseased heart impact immune cells and their crosstalk during tissue regeneration. #FCVB2024 #ESCbasicscience European Society of Cardiology

Innovative work by Miguel López-Unzu on mechanical homeostasis and remodeling in the myocardium. ❗️Loss of Titin’s mechanical functions leads to deregulation of cardiomyocyte adhesions and triggers fast, non-canonical fibrosis. #FCVB2024 #ESCBasicScience European Society of Cardiology

Highlight from one of this afternoon’s moderated poster sessions, Anke Smits talking about how single-cell RNA sequencing of the human fetal epicardium reveals several new genes involved in regulation of epicardial activation🫀🔍 CVCB Leiden #FCVB2024 #ESCbasicscience European Society of Cardiology

Lovely talk by Carolina Balbi on the secreted extracellular matrix protein Periostin in cardiac regeneration. ❗️CPC-derived #exosomes promote cardiomyocyte cell cycle-reentry via a short POSTN isoform on their surfaces. thno.org/v11p5634.htm #FCVB2024 #ESCbasicscience European Society of Cardiology

Amazing job by our colleague Clarissa Becher with her presentation at #FCVB2024 ❤️‍🩹 ❗️ BMP9 attenuates IL-33 signaling and prevents endothelial-to-mesenchymal transition in pulmonary arterial hypertension. CVCB Leiden #ESCbasicscience European Society of Cardiology

#FCVB2024 moderated poster session on Molecular mechanisms in cardiovascular disease. Proud of Giorgia presenting her PhD project 😍 #ESCBasicScience European Society of Cardiology Alessandra Lodrini Rui Adão Monika Gladka Annette Neele Jan Willem Buikema

Excited to dive into cardiac lymphatics with Brakenhielm‘s presentation. ❗️Lymphatic-immune crosstalk plays a prominent role in cardiac lymphangiogenesis in cardiovascular disease. #FCVB2024 #ESCbasicscience European Society of Cardiology

Intrigued by prof. Ingrid Fleming’s work on regulating lymphatics by novel lipid mediators. ❗️Modulation of lipid metabolism can induce angiogenesis and lymphangiogenesis. #FCVB2024 #ESCbasicscience European Society of Cardiology

Dr. Joaquim Miguel Vieira just gave an excellent talk on the role of macrophages in cardiac lymphangiogenesis. ❗️the macrophages-lymphatics crosstalk is important to resolve inflammation and promote regeneration after myocardial injury. #FCVB2024 #ESCbasicscience European Society of Cardiology

Wonderful presentation by Giulio Ciucci on how mechanical load regulates the proliferation of multiple cell types. ❗️Unloading of the heart promotes proliferation of cardiac cells ❗️Loading and cardiomyocyte beating inhibit cancer cell growth in EHTs #FCVB2024 #ESCbasicscience

LIVE from #FCVB2024: Tomasz Guzik shares his top tips & tricks in reviewing #scientific papers Read more in the featured article from the session here: academic.oup.com/cardiovascres/… European Society of Cardiology European Society of Cardiology Journals #CardioX #CVD #PeerReview #CardiovascularResearch

We start the last day of #FCVB2024 with prof. Chantal Boulanger’s exceptional talk on cardiac extracellular vesicles. ❗️extracellular vesicles from the infarcted heart reach the blood stream and transfer proteins to remote organs with effects still unclear. #ESCbasicscience

Prof. Lina Badimon dived into her studies on extracellular vesicles in cardiovascular disease. ❗️circulating microvesicles appear as markers of diseases like familial hypercholesterolemia & heart failure. Challenge: easy detection for clinical purposes! #FCVB2024 #ESCbasicscience

Prof. @VaderPieter’s exciting presentation on delivery of mRNA to damaged myocardium by lipid nanoparticles. ❗️Ischemia-reperfusion injury leads to increased vascular permeability, enabling extravasation of LNPs and delivery to different cardiac cells #FCVB2024 #ESCbasicscience

Dr. Aida Collado just presented her work on red blood cell-derived extracellular vesicles. ❗️Red blood cell-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through a mechanism involving arginase 1. #FCVB2024 #ESCbasicscience European Society of Cardiology

Last but definitely not least! Full room for closing special session by Prof. Manuel Mayr (Manuel Mayr Lab) on omics approaches to uncover new mechanisms in cardiomyopathy at #FCVB2024. A key takeaway: check for concordance between your mRNA and protein levels! #ESCbasicscience

ESC Basic Research Fellowship awardees, Dr. Molly O'Reilly and Dr. Myra Chavez, present their research at the closing session of #FCVB2024. Inspiring work! 👏🏻 #ESCbasicscience European Society of Cardiology

#FCVB2024 comes to an end! It was fun to be part of the Social Media team for this conference 🗣️ Next edition: #FCVB2026 in Leuven, Belgium. European Society of Cardiology