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A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance: nature.com/articles/s4159…

Online Now: Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin dlvr.it/TJZbHW

This is a great review on using nanopores to sequence proteins. Out today. It covers how nanopores work, why they haven't historically been able to sequence individual proteins, and how researchers are adapting them to solve those problems. Clear writing throughout.

Toward single-molecule protein sequencing using nanopores go.nature.com/3FL0g3k

Single-molecule m6A detection empowered by endogenous labeling unveils complexities across RNA isoforms dlvr.it/TJfZgP

Breaking up translation condensates in cancer: nature.com/articles/s4155…

#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler. nature.com/articles/s4159…

The Miska Lab is a diverse & interdisciplinary RNA powerhouse! 💪🧬 We tackle fundamental questions in RNA biology, from epigenetic to RNA structure & function across C. elegans, cichlids fishes, and mammalian cells. Curious? Stay tuned

Two updates with this project! First, this work is now published here: academic.oup.com/nar/article/53… Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pigpen

Immiscible proteins compete for RNA binding to order condensate layers: biorxiv.org/content/10.110…

Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors dlvr.it/TJgSdn

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes: nature.com/articles/s4146…

New online! Transcriptomics in the era of long-read sequencing bit.ly/3FG0rwU

🥳 Happy #DNADay! 🧬 What better way to celebrate than with cycleHCR: one of our newest tools, developed by the Liu Lab, that uses a novel DNA barcode system to track hundreds of RNA & protein molecules in single cells within thick biological samples ➡️ janelia.org/news/new-metho…

New online! Advances in single-cell DNA sequencing enable insights into human somatic mosaicism bit.ly/3EGIyxQ

New online! SLAM-RT&Tag: spatiotemporal profiling of RNA within nuclear compartments in situ bit.ly/4doyxSM

Meet the gatekeeper of the nucleus: the nuclear pore complex (NPC), in 3D! Learn more at smart-biology.com #biology #science #animation #3D #EdTech

Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity: Cell Reports cell.com/cell-reports/f…

The C-terminal domain of EDC4 scaffolds P-body assembly, and its disruption by the NBDY 22–41 peptide activates the p53 pathway and limits tumor proliferation, linking P-body dynamics to gene control. bit.ly/448qaGM

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets dlvr.it/TLyB5j