Thanks to Gerald Zamponi and colleagues for highlighting our work on the mysteries of gabapentin action, calcium channels, and the EMC holdase. nature.com/articles/s4159…

Fun (and very stylish) day to celebrate recent lab papers. Thanks to Butch, Rebecca, and Phil Enkidu Winery for a great afternoon and Sonoma's best wines. Enjoyed the sun, wine, and Jack London State Park Jack London Park before returning to our cold, summery, fog-covered SF😎

Thanks to the Jura lab Natalia Jura for a fun, not quite yet the end of the week, happy hour! See you all in lab tomorrow.😀

Chen et al. report the structure of a gabapentin-bound brain and heart calcium channel revealing the gabapentin binding site and isoform-selective binding determinants. Zhou Chen Abhisek Mondal Dan Minor UC San Francisco #gabapentin #calciumchannels nature.com/articles/s4159…

Have you heard dis information?

Happy to share our new chemogenetic system CATKLAMP to activate TREK channels irreversibly, probe fundamental channel mechanisms, and turn off neurons. Great work from team Chemogenetic K2P🎉🎉 Parker Deal Abhisek Mondal Marco Lolicato @IsacoffLab Adam Renslo biorxiv.org/content/10.110…

Minor lab Halloween fun. Super good looking 😀

Very nice talk by Abhisek Mondal on the structure of gabapentin bound to CaV alpha 2 delta! Important work advancing our understanding of chronic and neuropathic pain treatment!

Great presentation by ⁦Abhisek Mondal⁩ on our work on defining the gabapentin binding site on calcium channels. Come to poster B381 ⁦Biophysical Society⁩ later this morning for discussion of his work.

Further evidence of high-resolution capabilities at 100 keV with a side-entry cryo holder using the Gatan Microscopy Alpine detector. It even performed better than the K3 on a small sample - Great collab with colleagues in Verba lab UC San Francisco biorxiv.org/cgi/content/sh…

Please RT and encourage students and early career researcher folks to apply for this fantastic ECR venom symposium! Join us for the 2024 venom GRS in beautiful Portland Maine from 10-11 August! #GRCvenom24 is 11-16 Aug! Register here: tinyurl.com/yd8fw8fa

Spending time outside isn’t just good for our bodies, it’s great for our #MentalHealth too! Thanks to Campus Life Services, our community took the opportunity to de-stress, meet & brush llamas in Koret Quad at Mission Bay.

Whats the point of having the results "open" when the way in which the results are derived is "secret sauce"? Like seriously what kind of science is this and would the scientific community have put up with anything like this in other fields? Why are structural biologists silent?

Congratulations to Parker Deal Abhisek Mondal Adam Renslo @IsacoffLab [email protected] Marco Lolicato and the whole CATKLAMP team !! cell.com/cell-chemical-…

Really happy that our paper on solving the crystallographic phase problem using neural networks is out in Science Magazine. Thanks to Dr Toms Rekis and Anders Østergaard Madsen for a great collaboration. science.org/doi/10.1126/sc…

And we're off! After 2 years of planning, the GRC Venom 2024 is underway! Super keen for a week of cutting edge venom and toxins science! 🐍🕷️🪼🐜🐝 #GRCVenom24 Anna Klompen, PhD Eivind Undheim Darin Rokyta

We report the 3D architecture and mechanism of touch detection by the Pacinian corpuscle. Contrary to the textbook knowledge, the outer core is dispensable for frequency detection. A new study by Luke Ziolkowski and Yury Nikolaev biorxiv.org/content/10.110…

Our newest rouges' gallery of saxitoxin congener structures with the High Himalaya frog saxiphilin. 🙏to Sandra Z, Dr Samantha Nixon, and Zhou Chen and our awesome collaborators DuboisLab Marta Filizola NOAA's Ocean Service biorxiv.org/content/10.110…

Development of covalent chemogenetic K2P channel activators. Research by Dan Minor, Parker Deal, Abhisek Mondal, Adam Renslo, @IsacoffLab, [email protected], plvdac CellChemicalBiology #SfN24 hubs.li/Q02R-ML70

OK, now they have REALLY gone too far.