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What's next for Dr. Aashish Manglik, winner of the 2024 Bowes Biomedical Investigator award? The cell signaling expert says he's excited to explore new territory: "UCSF is a wonderful place to set up your own shop & get both support & meaningful critique." ucsfh.org/3SLjskv

Today we remember and celebrate the life of Bill Weis. Our friend, colleague, & mentor. We scientists are lifelong learners by temperament & necessity. Bill fueled our learning daily. 1/n

Excited to welcome Carol Robinson, Dr. Lee’s Professor of Chemistry at University of Oxford & Director of Oxford’s Kavli Institute for Nanoscience Discovery for a seminar UC San Francisco on 03/20, hosted by Aashish Manglik! Join us: qbi.ucsf.edu/seminar-robins…

Ever wonder how microbes interact with the host at a molecular level? Check out our latest paper in @nature with Noah Palm and Curtis Huttenhower where we developed a host:microbe profiling technology, BASEHIT, to atlas interactions between commensal microbes and the human exoproteome.

So excited to see our work on "Profiling the proximal proteome of the activated μ-opioid receptor" using APEX-based proximity labeling and quantitative mass spec published today. It is the result of an amazing team effort! nature.com/articles/s4158… #TeamMassSpec #Proteomics #GPCR

I am truly honored to receive the HFSP long term fellowship (LTF) 🥳 I'll be working with Aashish Manglik as a postdoc UC San Francisco Very grateful for this opportunity and can't wait to do great science !!

How to pick a problem. Today in Cell. 1/53 cell.com/cell/fulltext/…

Our new paper on structure-based discovery of novel CFTR potentiators via large-scale docking is out in Cell! cell.com/cell/fulltext/…

Scientists Discover a New Hormone that Can Build Strong Bones | UC San Francisco Thank you ⁦@LauraKurtzman⁩ for a great summary of team effort with ⁦@dr_ambrosi⁩ ucsf.edu/news/2024/07/4…

How do cells communicate? UCSF's Aashish Manglik explored cellular communication through specialized protein receptors at the 29th annual Byers Award Lecture. UCSF School of Pharmacy tiny.ucsf.edu/MAnu3P

In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on the mammalian ribosome out today in nature rdcu.be/dRAQY collab with Deuerling Lab Shu-ou Shan Caltech Swiss National Science Foundation European Research Council (ERC) ETH Zurich

Yann LeCun Sebastian S. Cocioba🪄🌷 Although you don't cite our critical paper (same time) where we showed you could fold into correct 3D structural topology from the inferred contacts. This is the paper showed the power and gave a nice strong premise for developing AF - journals.plos.org/plosone/articl…

We are recruiting a young researcher to join our dynamic lab at UCSF - this is a great opportunity if you would like to get some research experience before graduate or medical school! aprecruit.ucsf.edu/JPF05305. Please RT!

Excited to share a new preprint about my postdoc work in the von Zastrow lab! Using conformational biosensors, we investigated the mechanism by which the mu-opioid receptor increases G protein activity on endosomes. biorxiv.org/content/10.110…

Two exciting #postdoc opportunities for #microscopy #developers and #biologists to join our team Centre Of Membrane Proteins and REceptors Uni of Birmingham! The Wellcome-funded project aims to develop a #AI driven #automated platform for high-throughput 5D #imaging applied to #GPCR #signaling!

Thrilled to share our findings on NINJ1 autoinhibition, now online in nature. Big thanks to the amazing team Vishva Dixit Melissa Truong Matt Johnson Alexis Rohou and many others. Video by the talented, twitterless Sergei Pourmal (1/3)

Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:G protein complexes. We show this at kappa-opioid receptors by cellular, radioligand binding and cryoEM studies. A 🧵: USC USC Dornsife College of Letters, Arts & Sciences nature.com/articles/s4158…

Please check out our recent work led by brilliant student Matthew Howard jointly mentored with Willow Coyote-Maestas. Willow and I are recruiting joint postdocs!

I am so incredibly lucky to get to work with brilliant postdoc Jose A Velilla. Jose is taking on some of the most ambitious ideas that Mark and I dreamed of collaborating on for years - the HHMI Hanna Gray fellowship will enable him to dream ever bigger!

You’ve heard of vibe coding—meet vibe protein design. Click, launch, and watch the binders roll in. That’s what we're unveiling with Ariax Bio today.