🎙️ New Annals of the Rheumatic Diseases #podcast !

🦋 Go over the 2023 EULAR #SLE recommendations with leading authors A.Fanouriakis & D.Boumpas

🎧 bit.ly/4bgIy2s

George Bertsias Chris Wincup Ioannis Parodis Laurent ARNAUD Lupus Europe Maria Tektonidou Ian N Bruce Marta Mosca

Can the amyloidosis progression to end-stage renal disease be stopped? Check out our latest publication:

▶️ bDMARD led to prevention of renal disease
▶️ differences accross AA background and bDMARD used

🔗 bit.ly/44dZTGK

What is new on autoinflammatory diseases? Check out our latest publication CANDLE/PRAAS:

▶️ flare criteria based on laboratory and clinical parameters
▶️ baricitinib dose reductions led to flares
▶️ role of IFN score as flare criterion

🔗 bit.ly/3w3dS5L

COVID-19 mRNA vaccine has proved remarkable efficacy, so what is next for inflammatory rheumatic diseases (IRD)?
▶️ advantageous platform for technical challenges
▶️ possible multivalent vaccines
▶️ ongoing trials
🔴 specific studies in IRD needed

🔗 bit.ly/3Jvr2vy

Wha is the role of monocyte heterogeneity in #lupus ?

▶️ subset-specific epigenetic and transcriptomic programmes identified
▶️ association with disease activity
▶️ lupus-specific subsets with distinctive functions revealed (complement and IFN related)

🔗 bit.ly/4d6NPuW

What is new in the pathogenesis of PAPA syndrome?
▶️ PSTPIP1 activates pyrin inflammasome
▶️ Increased IFN-g production in lesional skin
▶️ JAKi abrogate these phenomena -> beneficial effect in patients

🔗 bit.ly/3U6N4tq

CannaLab Massimo -Max- Gadina

☠️ ☠️ ☠️
Rheumatoid Arthritis + Comorbidities = Deadly Combination

👉 Check out this population-based study on 1643 patients with prevalent RA
🔎 Studying cluster patients with RA based on comorbidities, and their prognosis

🖇️ bit.ly/3W8AbBB

Potential and pitfalls of repurposing the CAR-T cell regimen for the treatment of autoimmune disease

☯️ Will this new option transform the landscape of therapeutic options for previously difficult-to-treat autoimmune diseases?

👉 bit.ly/49C5FmI

🗞️ What's in the current Annals' issue?

Shift in perspective: autoimmunity protecting against #rheumatoid arthritis

🔎 What if the ACPAs are protective in pre-RA instead of pathogenic?

👉 Check out the interesting insights in
ard.bmj.com/content/83/5/5…

#antibodies

Disentangling the riddle of #SLE with #APS

Blood transcriptome analysis reveals a less pronounced IFN-signature and distinct molecular profiles in venous versus arterial events

🔬 Whole-blood RNA-sequencing
⭐ 299 SLE (108 SLE-aPL+)
⭐72 matched HC

👉 bit.ly/3PWPgCb

Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosis

🔬 A study based three complementary mouse models

👉 bit.ly/4cTDT85

#systemic_sclerosis
#animal_models

🤔 What is worse for #cardiovascular disease in ankylosing #spondylitis - continuous low or intermittent high #NSAIDs ?
🔷 19706 Korean patients studied
🔶 higher dose of NSAID treatment was associated with a higher risk of CVD❗
ard.bmj.com/content/early/…

📣 Safety of #JAKi or #TNFi in rheumatoid #arthritis and #spondyloarthritis ::
🔹 6826 real-world patients: 52% RA, 25% PsA, 23% axSpA
🔸 IRR of infections and GI events higher with JAKi ❗JAKi were prescribed in patients with poorer prognosis❗
bit.ly/3PVVoLe

🎯Connecting #osteoarthritis genetic risk loci with genes in chondrocytes highlights PAPPA and SPRY4 as interesting novel effector genes in OA🙌
👉 the whole dataset is available in an open repository for others to dig in #NCBI GSE260760👍
ard.bmj.com/content/early/…

🤔 Is specific #Tcell receptor blockade a new treatment avenue in #spondyloarthritis ? ☝️ Read what the experts think in this 'Views on news' article ard.bmj.com/content/early/…

✔️ The Outcome Measures in Rheumatology ( #OMERACT ) Ultrasound Working Group generated a consensus-driven ultrasound dactylitis score for psoriatic #arthritis 😍🖐️ =GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS)👍 see the details here 👉ard.bmj.com/content/early/…

A newly reported application of #AI 💻in #rheumatology from the 🇬🇧: Text analysis of medical records to help advise patients on shielding measures during the COVID pandemic 🦠. Can it save time and resources in future pandemics?

ard.bmj.com/content/early/…

Modulation of immunological pathways by Type I interferon blockade with #anifrolumab in the 🌷1 and 🌷🌷2 trials in #lupus .

ard.bmj.com/content/early/…

Metabolic changes in sera of patients with #rheumatoidarthritis or #spondyloarthropathies are indicative of cancer or paraneoplastic syndroms, a new study from 🇩🇪 shows. Will it facilitate an earlier diagnosis of #cancer in this population?

🔗 bit.ly/3TAsSje

Should all patients with #polymyalgia rheumatics be screened for #giantcellarteriitis with vascular #ultrasound ? A recent viewpoint summarizes the evidence:
📊prevalence of subclinical GCA may be as high as 25%

ard.bmj.com/content/early/…