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We are looking for a legal expert(s) who can help us write a review of the current statutes that govern data flows for #AMR for both individual and population health benefit. If you are interested can you DM me or @AIex_Howard

Alex Howard @AIex_Howard at #PintOfScience giving a wonderful talk about AI and UTI as part of #CAMONet Faculty of Health and Life Sciences and @Wellcome_AMR . Clear, innovative and very engaging with great questions from the audience about sharing data, accountability and finding new ways to tackle #AMR

Yesterday, our network gathered in Liverpool to celebrate our unique global partnership, which works towards addressing the many complex problems surrounding antimicrobial resistance #AMR @Wellcome_AMR Marc Mendelson

Pro Vice Chancellor of Faculty of Health and Life Sciences spoke about the importance of Liverpool’s expertise in pharmacology and infectious diseases as a key element of our network

And Chibuzor Uchea, Research Manager in Drug Resistant Infections Wellcome expressed the urgent need to address AMR and how proud he is to support CAMO-Net.

We are so excited to bring you all of the latest AMR news and events from around the world so make sure to follow CAMO-Net so we can keep in touch!

Happening tonight Lymm Festival - The Science of Stranger Things with Prof Carsten Welsch University of Liverpool Physics Cockcroft Institute

Antimicrobial Pharmacology PhD #LivUniGrad William Hope

Here, we developed PBPK models for fosfomycin and amikacin in neonates and used it to assess the predicted efficacy of these agents for the treatment of neonatal sepsis. William Hope livUni_ICAT

It is a pleasure to announce the publication of our paper characterising the pharmacodynamics of emergent antimicrobial resistance to meropenem in pneumonia caused by Pseudomonas aeruginosa in mBio. 1/n doi.org/10.1128/mbio.0…

Doses of antibiotics are generally optimised to produce optimal bacterial killing effect. However, the effect of resistance emerging to these agents is not just not taken into account; it is typically not even characterised as part of the drug development process. 2/n

This is the fundamental root cause of all antibiotic resistance. We use antibiotics at a dose that kills the bacteria enough to treat an infection, but not to suppress the resistance that emerges (either in the infection or elsewhere in the body) 3/n

This is especially a problem in pneumonia. These infections have a large volume of infective material with large numbers of bacteria, which are high enough that natural rates of genetic mutation provides opportunity for mechanisms of antimicrobial resistance to develop. 4/n

This is particularly true for hospital-acquired pneumonia (HAP), which are caused more often by Gram-negatives (with P. aeruginosa being a common cause), which have a greater propensity to develop resistance on treatment. 5/n

This happens even with newer agents. In the clinical trials for testing meropenem-vaborbactam and cefidercol for HAP, whilst both produced a successful trial outcome, emergence of resistance to both was seen in each trial. doi.org/10.1007/s40121… doi.org/10.1016/S1473-… 6/n

Existing pre-clinical models don't adequately measure antimicrobial resistance in a way that readily translates to a clinical setting. Here, we sought to develop one. 7/n

You can find out more about University of Liverpool's important #AMR work here ➡️bit.ly/4chXgYi William Hope Faculty of Health and Life Sciences CAMO-Net

Bayesian Estimation of AMR prevalence (BEAR) is an algorithm to improve population infection management decisions (e.g. antimicrobial formularies, IPC policy) by enabling more precise & resource-efficient estimation of AMR prevalence doi.org/10.1093/jac/dk… @AIex_Howard #JACNews

This unique analysis combines pharmacokinetics and pathogen genomics to explore the relative contribution of these factors to clinical outcomes from HIV-associated cryptococcal meningitis. William Hope John Perfect Katharine Stott journals.asm.org/doi/10.1128/mb…

In Liverpool 🇬🇧 this week we hosted a discussion on the upcoming United Nations General Assembly high-level meeting on #AMR and Liverpool's role in the global effort to address the crisis. With Tony Blair Institute for Global Change, Andrew Gwynne MP & Wellcome 🇺🇳 Read about it on our blog 👇 camonet.org/2024/09/13/a-g…