ATVB April Featured Article: Authors report that in patients with stable coronary artery disease, antagonism of PAR4 has additive antithrombotic effects when combined with other antiplatelet therapies, such as aspirin or ticagrelor or their combination.

Very happy to share ATVB April Featured Article - Very interesting study demonstrating that prior preeclampsia in mice devoid of LDLR increases plaque formation but without affecting metabolic risk factors- implications for later consequences of this pregnancy-related disorder

#ATVBnet : In this blog post get to know our Senior Editor Elena Aikawa #meetus #atvb
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Latest issue of ATVB - a critical evaluation of proposed biomarkers for PAD and the genetic evidence!

Happy to share April ATVB Editor pick - read about the role of postnatal lymphangiogenesis in a mouse model of autoimmune valvular carditis. Elegant work with implications for the study of rheumatic heart disease

By elucidating endothelial regulation of insulin sensitivity via Arf6 signaling, this study provides a new mechanism of vascular dysfunction and diabetes Andrew Horn Denisse Gabriela
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Important new study in ATVB - addressing PCSK9 inhibition in patients 10-17 years - data support a trial of PCSK9 inhibitor therapy regardless of estimated residual LDLR function. Thanks to the authors for contributing this work to ATVB!

Our ATVB Editors are so thankful to the many members of our ATVB community for their outstanding contributions to Centennial Collection. Thanks, too, to the expert reviewers who provided most helpful and constructive comments! We are thrilled to support and celebrate the AHA!

New Approaches for Targeting PCSK9: Small-Interfering Ribonucleic Acid and Genome Editing
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Congratulations and thank you to Alan Daugherty and colleagues for this excellent contribution to ATVB journal!

Congratulations Burak! Very happy for you! Good luck in all your next steps!

Immensely proud of Sharnendra (Sharn) Sidhu, MD for producing this important review on the role of duration of excess adiposity exposure in the pathogenesis of diverse CVD - an area in great need of more research attention!
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NYU CVD Prevention NYU CVRC

COVID-19 and its impact on the immune system and tissue factor release - new insights uncovered through a multi-omics approach - implications for the severity of vascular complications in this disease - Read about this work in the latest issue of ATVB journal!

Peripheral arterial disease (PAD) is a major cause of morbidity and mortality - in the latest issue of ATVB, authors show that remnant cholesterol is associated with PAD. Risk for myocardial infarction was linked to both remnant and LDL cholesterol.

Today we celebrate our devoted volunteers who dedicate their lives to helping others. We are so grateful today and every day for all that you do. ❤️ ❤️

#NationalDoctorsDay

Once again, many CONGRATULATIONS and sincerest THANKS to the ATVB journal Digital Strategies Team (DST) for a simply outstanding Science Chat today!

New in ATVB: Zhang and Wang and colleagues report that GLP-1(32–36) modulates metabolic reprogramming toward glycolytic flux together with with GLP-1R for improved angiogenesis in high glucose–exposed EPCs and T1D murine models. Insights into therapeutic opportunities in PAD.

Fascinating study in latest issue of ATVB- results highlight that virus-specific CD8+ T-cells are enriched in atherosclerotic lesions. Authors show that the potential contribution of these CD8+ T-cells to inflammation may be via antigen-independent mechanisms!

I'm honored to have contributed to this ATVB: An AHA Journal #AHACentennialCollection article w/ Elena Aikawa, sasha, Robert Levine, & Sir Magdi Yacoub. We offer a perspective on future challenges & therapeutic opportunities in valvular heart disease!

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Check out my commentary in ATVB about lincRNA SIMALR and atherosclerosis #lncRNA
ATVB: An AHA Journal