🔥Telegram İfşa

Exhausted T cells impede immune response in cancer. Immune checkpoint inhibitors, especially CTLA-4 blockade, show promise in rejuvenating T cell function for cancer immunotherapy. Gracie Jennah Mead writes. oncobites.blog/2024/01/17/cel…

There's still time to secure your place at our next Science and Innovation at Cancer Research UK DPhil in Cancer Science Open Day! Join us online on Thurs 5th September, 10am -12 pm, to learn how a DPhil could enhance your #CancerResearch career development. Register 👇 cancer.ox.ac.uk/study#open-day

doi.org/10.1101/2024.0… - check out our new preprint - discovery of Zfp263 as a key checkpoint of neutrophil development. Abhinandan says: “This discovery opens up new possibilities for targeting neutrophil-driven conditions, from inflammatory diseases to certain cancers."

Many cytosolic proteins are released by cell death. Why do some become autoantigens? In a team work led by Esther Jones and @LD53073604, we explore the story of a common autoantigen, TRIM21

PhD/DPhil applications at the Kennedy Institute of Rheumatology are now open for 2025! Check out all the projects; and then apply to our project 😀! Advertised with Gerard Lab to study macrophage signalling in tumours.

In Sjögren's disease, the body's alarm system mistakenly treats a helpful part like an intruder, causing a chaotic response. @LD53073604 JelenaBezbradicaLab @maadulon Kennedy Institute of Rheumatology bioRxiv Immunology biorxiv.org/content/10.110…

How can we extend responses to KRASG12C drugs? Out now in Nature Communications, combining Revolution Medicines’ RAS(ON) G12C-selective inhibitor with a SHP2 inhibitor and immune checkpoint blockade to study their effects on KRAS-mutant lung tumours of varying immunogenicities.

We are looking for a PhD student to study the immune relationship between cancer and atherosclerosis. Get in touch if interested! kennedy.ox.ac.uk/study-with-us/… cancer.ox.ac.uk/study#dphil-pr…

Thinking of doing a PhD? Why not apply to study at Oxford? The Kennedy Institute @KIROxford are holding their first open day. Join us for… 🧫 Lab tours 🙋‍♀️Meet our students 📝Taster lectures 🔬Technology talks Find out more and book your place! 👉 kennedy.ox.ac.uk/study-with-us/…

For the first time, Kennedy Institute researchers have discovered the cellular basis of why some people respond to IBD treatment while others do not. This patient-centred study could guide new therapies for #CrohnsDisease and #UlcerativeColitis. kennedy.ox.ac.uk/news/cellular-…

#LocationLocationLocation! 💥Our new Feature Review on the regional specialization of the immune response along #airways is out Trends in Immunology! We discuss anatomical, functional & microbiota factors controlling #innate & #adaptive #immunity! David Hoytema van Konijnenburg authors.elsevier.com/a/1jzXg5Eb0Rxn…

Cooperative motility emerges in crowds of T cells but not neutrophils biorxiv.org/content/10.110…

Why do some inflammatory bowel disease patients benefit from anti-TNF therapy whilst others do not? Our new Nature Immunology resource paper investigates this question by following patients before and after treatment: nature.com/articles/s4159… 👇

Wonderful study from Omer Dushek lab that is a real breakthrough. I think they've solved 1/2 the problem of TCR cross-reactivity. They can make the (in)famous A3A TCR (that resulted in lethal cardiac toxicity) completely safe! Go read it to understand how!

Our new work led by our fantastic PhD student Jose (Jose Cabezas-Caballero) showing dramatic reductions in TCR-T cell cross-reactivity without modifying the TCR. Part of this work relied on SPR-based Carterra to measure 163 TCR/pMHC affinities within 24 hours at 37 degrees.

Don't forget, our DPhil in Cancer Science Programme is now open for applications! For more information - or for details on how to apply - visit our website ⬇️ cancer.ox.ac.uk/study Medical Sciences MPLSOxford

Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer: Cell cell.com/cell/fulltext/…

Really pleased to see this Opinion Review out. The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases: Trends in Immunology cell.com/trends/immunol…

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: …rentprotocols.onlinelibrary.wiley.com/doi/10.1002/cp…