#Sepsis induced thrombocytopenia
1️⃣measuring PLT
2️⃣common/associated w outcome
3️⃣immune mechanisms
4️⃣vascular integrity & organ injury
5️⃣differential diagnoses
6️⃣ABTs
7️⃣DIC? not the same
8️⃣bleeding more vs PLTs count
9️⃣NOT exclude thrombosis
🔟transfuse?
🔓rdcu.be/dHZul

🫁 Tidal volume in #ARDS ?? We should continue using protective MV but, vs using fixed cut-of (6 ml/kg PBW), maybe better individualize VT considering multifactorial contribution of ∆P, CRS, ECW, PEEP + regional lung mechanics.
#FOAMcc Intensive Care Medicine
🔓rdcu.be/dHUzd

Optimal tidal volume in #ARDS ?
🫁is ΔP indicator of unsafe VT & does it directly impact on outcome?
🫁what factors can influence CRS + interplay between VT & ΔP?
Individualize VT considering multifactorial contribution + regional lung mechanics.
#FOAMcc
🔓 rdcu.be/dHUzd

💉Empirical antimicrobials in #ICU ? Timely & appropriate ABT therapy paramount in critically ill patients presenting with suspected infection, potentially leading to #sepsis or septic shock. On Intensive Care Medicine a #FOAMcc step-by-step approach for prescription
🔓 bit.ly/4ai3zss

Empirical antimicrobials in #ICU ? Review aimed to provide a step-by-step approach for prescription:
⏱️ assessing need & urgency
🧫 pathogen profiling
⚖️ selecting the right arsenal
🔮 future perspectives
Free to read #FOAMcc on Intensive Care Medicine
🔓 bit.ly/4ai3zss

🕯️Dying patient in #ICU : framework to prevent poor quality of care/moral distress among staff/families. As shared decision to limit life-sustaining treatment reached & approaching EoL accepted, pivotal caring consistently with pt's values/preferences.
🔓 rdcu.be/dHGQV

Excellent update on LV-unloading while on VA-ECMO. While not every VA-ECMO patient may need an LV vent (think pulmonary embolism), missing the window of LV unloading in patients that do need it may be costly.

🩸Hemostasis testing in #ICU ? Judicious use crucial in guiding decisions making, optimizing care/outcomes, as many critically ill patients exhibit coagulation abnormalities (thrombosis/bleeding) associated with underlying diseases
#FOAMcc on Intensive Care Medicine
🔓 rdcu.be/dHEMY

Understanding long-term outcomes in cardiogenic shock survivors is an important area of future research, and our new ICES paper looks at mental health outcomes in this population. Just published in Intensive Care Medicine.

🔓rdcu.be/dGDlC

link.springer.com/article/10.100…

Hemostasis testing in #ICU to evaluate
🩸thrombotic &
🩸bleeding disorders
with conventional/second line tests + VETs may improve individualized protocols leading to more targeted/effective interventions ⬇️ unnecessary transfusions/complications. #FOAMcc
🔓rdcu.be/dHEMY

Cardiogenic shock in 2024:
🫀 #extracorporeal life support #ECLS
🫀 left ventricular unloading strategies in #ECMO
strategies & evidence from recent trials (& beyond)
Free to read #FOAMcc #FOAMecmo on Intensive Care Medicine
🔓 rdcu.be/dHzLz

Diagnosing #sepsis ? Problematic
🧫pathogen identification frequently lacking
🔍dysregulated host response non-specific + sterile inflammation can mimic #sepsis
🔎none of new biomarkers widely adopted
But impressive technologies (also POCT) in development
🔓rdcu.be/dHhsp

Interesting and Important Discussion on the divergence and convergence between the new ARDS guidelines

Diuretics in #ICU
🫘 what the indications?
🫘 how to monitor?
🫘 continuous infusion more effective vs intermittent dosing?
🫘 combining w albumin to improve effectiveness?
🫘 furosemide stress test
🫘 how to manage diuretic resistance
#FOAMcc Intensive Care Medicine
🔓 rdcu.be/dG6xx