We have a tenure track opening for a computational scientist with exciting ideas for #machinelearning in molecular biology at the MRC Laboratory of Molecular Biology, incl generous core funding from Medical Research Council & an unparalleled scientific environment. RTs appreciated! 🤗
jobs.sciencecareers.org/job/657824/res…

After six fantastic years at MRC Laboratory of Molecular Biology, I'm returning to Denmark to join Molekylærbiologi - Molecular Biology! Starting August 2024, we'll combine biochemistry, cryoEM, and single-molecule imaging to study how DNA damage is recognized and repaired.

sites.google.com/view/alconlab

Good things come to those who wait . . . After a phenomenal amount of work from our WHO-funded consortium our pre-print describing risk-free poliovirus vaccines is now online! biorxiv.org/content/10.110… #Vaccineswork #virology #VLPs 1/2

I am delighted to share the latest preprint from our lab, which was work that was conceived and led by Jeannette Tenthorey during her postdoc and during the first few months of her independent lab at UCSF.

biorxiv.org/content/10.110…

TL;DR: Indels matter. A lot.

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What is the origin of our body? Our paper Cell shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta.
cell.com/cell/fulltext/…

This is a blatant misrepresentation of our work science.org/doi/10.1126/sc…. Our study does not in any way suggest that the application of SPF50 sunscreen “blocks our natural defences” or is detrimental to health.

Many people are wondering how we can monitor this H5N1 situation. We sequence the whole virome from wastewater, and, well, H5N1 started showing up in our samples.

medrxiv.org/content/10.110…
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We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. zenodo.org/records/111798…

Super clear aurora over #Cambridge tonight

Ever wondered how different caspases select their substrates? Turns out, they have their own styles. Check out our study: cell.com/immunity/abstr… Immunity Cheers to the fantastic teamwork! Jonathan Kagan Kay Lab Prof. Hao Wu. 🥳🧵(1/7)

Single-dose expanded Tregs do not preserve clinical β cell function in new-onset type 1 diabetes (phase 2 trial), despite their in vitro efficacy Science Translational Medicine
science.org/doi/10.1126/sc…

Amazing science

Sad to see the AlphaFold3 code not published despite Nature Portfolio policies of open science nature.com/nature-portfol…

NEW

Renewable power reaches record 30% of global electricity in 2023

🌞Driven by phenomenal growth in wind and esp solar

📉'Critical turning point' as burning fossil fuels for electricity will likely start to fall this year

Analysis Ember

news.sky.com/story/renewabl…

We have also launched AlphaFold Server, a free platform that scientists around the world can use for non-commercial research. 🔬

They can harness AlphaFold 3’s predictions and test hypotheses with just a few clicks - no matter their technical expertise. →

Anonymous Comment found to explain why PhD/pdoc getting longer 'the amount of data needed per paper has gone up 8-10 fold since 1995. Editors want 4 papers worth of data per article and not limiting comments from reviewers that always ask for more' *How did this happen?*

A step towards a universal, pan-sarbecovirus vaccine
nature.com/articles/s4156…
Nature Nano HowarthSci Cambridge University and collaborators #nanomedicine

The DRC is facing a host of terrible outbreaks already including its worst cholera outbreak since 2017 and a large measles epidemic, plus battling anthrax, plague and mpox. I really hope that Ebola does not join the list!

People with 2 copies of APOE4 were known to have a high risk of #Alzheimers .
Today that changed to nearly 100% full penetrance
NATURE.med
nature.com/articles/s4159…

'Our results provide biochemical evidence that the HIV-1 capsid lattice conceals the genome from cGAS and that chemical or physical disruption of the viral core can expose HIV-1 DNA and activate innate immune signaling.' biorxiv.org/content/10.110…