Former MIT biologist David Sabatini, forced out after sexual harassment accusations, to lead new Boston team statnews.com/2024/04/30/dav… via STAT

... 'The litigation is ongoing.' ... <No comment> <No comment> <No comment> and ... back to business as usual.

FDA finalizes plan to regulate some lab-developed tests statnews.com/2024/04/29/fda… via STAT

'Overall, the FDA estimates that around 12,000 labs will have to start submitting their tests.' #LDT

This #AI Just Designed a More Precise #CRISPR Gene Editor for Human Cells From Scratch singularityhub.com/2024/04/25/thi… via Shay Hub

A #CryoEM structure of VMAT2, a transporter in synaptic vesicles, reveals the mechanisms of drug and neurotransmitter binding, inhibition, and transport. elifesciences.org/articles/91973…

#Biosimilars haven’t always yielded lower out-of-pocket costs for patients, study finds statnews.com/pharmalot/2024… via STAT

How #QuantumComputers Could Illuminate the Full Range of Human #GeneticDiversity : #Pangenomes singularityhub.com/2024/04/26/how… via Shay Hub
#genetics #genomics

Rat neurons repair mouse brains — and restore sense of #smell nature.com/articles/d4158…

Repair of CRISPR-guided #RNA breaks enables site-specific #RNA excision in human cells
science.org/doi/10.1126/sc… Science Advances

'What sequence characteristics define a #promoter ?':
Sequence basis of #transcription initiation in the human #genome :
science.org/doi/10.1126/sc…
#puffin #generegulation
How #DNA encodes the start of transcription:
science.org/doi/10.1126/sc…

Happy #DNA Day ! Here are some of my favorite DNA related speakers from #SynBioBeta2024 who will be discussing everything you need to know about the triad of reading, writing, and editing #DNA and how it forms the foundational bedrock of synthetic biology: synbiobeta.com/events/synbiob……

#LLMs might help burnout by drafting responding to patient portal messages in #EHRs . But is this a low-risk efficiency aid, or do #LLMs impact clinical judgement in more meaningful ways?

We investigated this in our new study out in The Lancet Digital Health: thelancet.com/journals/landi… 1/

GOOD ARTICLE:
#GenerativeAI is supposed to save doctors from burnout. New data show it needs more training statnews.com/2024/04/25/hea… via STAT #AI

'It’s really hard to evaluate generative text. .. That’s because its outputs are rarely completely right, or completely wrong.…

Pedagogical malpractice at UCLA medical school. I was prepared to see some questionable things in the mandatory “Health Equity” course, but what I saw was truly outrageous, requiring serious inquiry by the dean and the accrediting body. Aaron Sibarium

'Clonal expansion in normal tissues'
onlinelibrary.wiley.com/doi/10.1111/ca…

Mendelian inheritance revisited: dominance and recessiveness in medical genetics go.nature.com/3IgKyKW #Review by Johannes Zschocke, Peter H. Byers & Wilkie Lab
Med. Uni. Innsbruck UW Medicine MRC WIMM University of Oxford

BREAKING -- A new declaration, signed by dozens of biologists, neuroscientists, & philosophers, points to “realistic possibility” of #consciousness in reptiles, amphibians, fishes, certain mollusks, crustaceans, and insects. By me for Quanta Magazine quantamagazine.org/insects-and-ot… Nancy

Our latest preprint is here: shorturl.at/ckAV5. Using the UK Biobank, All of Us, and Open Pain portal, we propose a holistic framework to optimize the prediction of biomarkers for chronic pain.

It's not lost on me that one of my intellectual heroes Daniel Dennett (March 28, 1942 - April 19, 2024) passed on the same day as one of his, Charles Darwin (Feb 12, 1809 - April 19, 1882). Thankful to have known our modern day #Darwin . 'There is grandeur in this view of life...…

Super excited to share my latest work on precision nutrition and its role in addressing the global burden of obesity. Be it via genetics, circadian biology, SES, or metabolomics- precision nutrition is here to stay!! Learn more in our latest work-

advances.nutrition.org/article/S2161-…

New paper out on the efficacy of GPT 4.0 in answering commonly asked clinical questions across neurosurgery subspecialties!
sciencedirect.com/science/articl…