Excited to share new work on “Designing DNA With Tunable Regulatory Activity Using Discrete Diffusion.” We extend Score Entropy Discrete Diffusion to regulatory DNA! Work led by anirban sarkar.

paper: biorxiv.org/cgi/content/sh…

We are hiring! Looking for passionate postdocs interested in working on oxygen and vitamin metabolism. Come join us in beautiful SF! Competitive salaries ($77-90K/yr) and benefits. Email [email protected]. Job descrip: shorturl.at/k8H1u Gladstone Institutes UC San Francisco

Four papers from the lab this year so far, a few more to go. These papers are a good reflection of our venture into engineering RNA regulation for research and therapeutics. Contact me if interested in this research direction. #RNA #engineering #PrecisionMedicine #PostDoc

Are you interested in in vivo #CRISPR screens in mice to uncover mechanisms of #neurodegeneration ?
🐭🧬🧠

Apply for this SRA (technician) position in the UC San Francisco Kampmann Lab:

sjobs.brassring.com/TGnewUI/Search…

Great way to gain research experience before grad school!

Please RT/share!

🛠️New CRISPRi tool in Nature Biotechnology from LukeGilbert + lab!

Until now, scientists have been limited to targeting fewer than 3 genes at a time with CRISPRi. But what about when we want to study more complex combinatorial biology?👇

The Bioinformatics team led by Alex Dobin within the Computational Technology Center at the Arc Institute is seeking a Senior Scientist. Come join us and tackle some of the most fundamental problems in the intersection of biology and computation. boards.greenhouse.io/arcinstitute/j…

⚡After discovering the role of the ENPP1 enzyme in masking cancer from the immune system, Lingyin Li Lab has found a new enzyme, ENPP3, that also inhibits cGAMP-STING signal + anti-tumor immune response, preventing immunotherapies like Keytruda from working effectively.
🧵⬇️

What do #ML developers document or miss in data cards? 🔎We analyzed all the Hugging Face data cards (>7K) in new #ICLR2024 paper arxiv.org/abs/2401.13822
*Many data card recommendations are ignored
*Focus on Data Descriptions but less on Consideration for Using Data
* We

Join us at the Donnelly Centre for our next Donnelly #Seminar Series speaker: Hani Goodarzi from Arc Institute and UC San Francisco!

📅 Thursday, May 9 at 11am ET
📍 Red Seminar Room at Donnelly Centre | Zoom

Save Your Spot 👉 uoft.me/HaniGoodarzi

Our lab's debut paper is officially out RNA! 'Mapping RNA-Protein Interactions with Subcellular Resolution Using Colocalization CLIP' introduces a new method to probe RNA-protein interactions within specific subcellular compartments: tinyurl.com/yck4zkhv 1/

To cure age-related diseases, shouldn’t we study aged animals? 🐴🐒

The answer is yes, and Gordian makes this possible with our singular in vivo gene therapy screening platform.

Alex Knapp explains how this could change industry standards in Forbes: forbes.com/sites/alexknap…

Having watched Gordian Biotechnology start and grow from its early days (and from the sidelines), I am super happy to hear how far they have come!

As some of you might know, I have helped cofound this startup with colleagues Wendy Chung and Francesco Lotti focusing on RNA-based therapeutics. We are up and running at Alexandria LaunchLabs on the Columbia Medical Center campus. Now we are hiring #RNA enthusiasts to join!

Join the The DeepChem Project discord! We have an active community of contributors. Building better open source tools for AI-powered drug discovery is something we're passionate about. There's lot of ways for newcomers to get involved and contribute!

To understand the true relationship between 3D genome structure and gene expression, we measured both from the same cell with unparalleled sensitivity. Our LiMCA bioRxiv is now published in Nature Methods (with News & Views by dear LomvardasLab): nature.com/articles/s4159…

It is heartbreaking how little things have changed on this front since I moved to the US. Visa renewals are basically a game of roulette... anywhere between days to months. Permanent residency is opaque and really devastatingly long for the Indians and Chinese.

Terribly saddened by the loss of a close friend and mentor—the remarkable Lubert Stryer.
In med school in Romania, we had just one copy of his story-like textbook that made biochemistry fascinating and addictive. He was always amused to hear that we were fighting over that one

Deeply saddened by the passing of Lubert Stryer, father of FRET, pioneer of DNA and peptide microarrays, author of the famous Biochemistry textbook used across the world. Many may not know that he was also an extremely generous supporter of the arts and deeply passionate about

Many people have no idea how these things work.

For example, right now, as a Brazilian, I can't accept invitations to speak at conferences in Europe because my visa to work in the U.S. has expired.
I am not illegal; I have a work contract with the University of California until

This is indeed the case, many of us can’t travel; many students are trapped because of single-entry visas. Allowing hybrid attendance/presentation, meeting/conferencing in more visa friendly countries can help a bit.