Twitter Beğeni Hilesi

We are looking for an innovative basic scientist to join the faculty Dana-Farber Cancer Biology Department! We are a vibrant, supportive and collaborative department. Our research spans chemical and structural biology, signaling, metabolism and gene regulation. Apply now at ms.spr.ly/60179M8pb

Together with labs of Brian Liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises. biorxiv.org/content/10.110…

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. biorxiv.org/content/10.110…

Online Now: An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing dlvr.it/T8B4pm

Today in Science Magazine, together with my former colleagues at NIBR, we report the discovery and characterization of first molecular glue degraders of the WIZ transcription factor (TF) for fetal hemoglobin derepression and therapeutic consideration in Sickle Cell Disease. 1/10

How do combinatorial histone modifications impact gene expression? Our latest research aims to unravel this mystery. By engineering a mutant LSD1 enzyme (Y391K), we've disrupted the crosstalk between H3K4me and H3K14ac to explore its role in gene regulation. Check out our study!

I’m really excited to share a new pre-print in full collaboration with the lab of John Iafrate Mass General Brigham which was led by two superstars: Diane Yang and Stefan Andrew Harry who developed: Systematic Targeting of Protein Complexes with Molecular COUPLrs.

Incredibly honored to receive this prestigious recognition on behalf of Liau Lab, a reflection of their creativity, brilliance & hard work. They’re a super talented & fun group that I’m so lucky to work with. Also very thankful to my mentors. Still need to pinch myself every day!