Excited to co-host with Hélène Gleitz talks from Bo Porse and Haas Lab on cutting edge spatial and single cell proteomic technologies on behalf of ISEH. Free registration! Charles de Bock Kellie Machlus Vanessa Scanlon Katherine Bridge, PhD ASH European Hematology Association

TET2 mutational status affects myelodysplastic syndrome evolution to chronic myelomonocytic leukemia
doi.org/10.3324/haemat…
#MDSsm #MPNsm #CMML #TET2

Also wanted to add, here is the free share link for anyone who needs access:

authors.elsevier.com/a/1j8O41UYwnAsd

Check out the commentary on our #VEXAS article in Blood Journal

With just over a year left before I leave 🇬🇧, I'm feeling so sentimental...

Today, RGC has published an important paper in nature today, describing an analysis of close to a million human exomes (n=983,578) as a single variant call set (!). This is the largest and most diverse rare variant database created so far. This impressive feat is accomplished by

#CD8 + T-cell Differentiation and Dysfunction Inform Treatment Response in Acute Myeloid Leukemia
doi.org/10.1182/blood.…
#leusm Blood Journal AML Hub

To Mars and beyond. Space exploration and space medicine in Leukemia
nature.com/articles/s4137…
Leukemia Journal

#TP53 Mutations in Acute Leukemias and Myelodysplastic Syndromes: Insights and Treatment Updates
ascopubs.org/doi/10.1200/ED…
#leusm #MDSsm Valeria Santini Journal of Clinical Oncology

Targeting MCL1-driven anti-apoptotic pathways overcomes blast progression after HMA failure in chronic myelomonocytic leukemia
doi.org/10.1016/j.xcrm…
#CMML #MDSsm #MPNsm

#Inflammatory profile of lower risk myelodysplastic syndromes
onlinelibrary.wiley.com/doi/10.1111/bj…
#MDSsm

TP53 mutation screening for patients at risk of myeloid malignancy | Leukemia ⁦Devdeep Mukhopadhyay⁩ ⁦⁦⁦Laura Dillon, PhD, FACMG⁩ nature.com/articles/s4137…

Happy to share the second preprint from our lab! We analyzed the effect of chemotherapy on normal HSC genome and clonal architecture, and how it leads to therapy-related myeloid neoplasms.
biorxiv.org/content/10.110…

Great news to see this announcement!

An #age -progressive #platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis
doi.org/10.1016/j.cell…

🏃‍♂️🏃‍♂️
#Obesity -induced #inflammation exacerbates clonal hematopoiesis.

doi.org/10.1172/JCI163….

Excited to see our NIH NHLBI NIAMS Mayo Clinic Comprehensive Cancer Center collaboration looking at #VTE in #VEXAS syndrome out in this issue of Blood Journal! Over 40% of patients had a VTE. yael kusne MD PhD Atefeh Ghorbanzadeh Bhavisha Patel ashpublications.org/blood/article-…

🚨 Stephen D. Nimer, MD's recent study could lead to a new combination therapy for #leukemia . Featuring Sylvester's collaboration with first author Hidehiro Itonaga, Ph.D., and other researchers, learn how the study could inform #FDA development of new treatments: loom.ly/qRQEkfc.

Join us on June 8th at 12pm ET for a webinar on 'MDS Clinical Trial Basics & How SparkCures Can Find a Trial that is Right for You'. This webinar will provide valuable education on Clinical Trials and highlight the partnership between The MDS Foundation and SparkCures.

A novel application of XPO1 inhibition for the treatment of myelofibrosis ashpublications.org/bloodneoplasia…