youtube.com/watch?v=ztQphq… Nice study on curcumin and arthritis. Need a similar review of quercetin. Nicolas Verhoeven

frontiersin.org/journals/immun… Good review of anti-inflammatory activity of quercetin. Similar to curcumin inhibits TNF-a, IL-6, IL-1B. Also inhibits secretions of mast cells.

Clinical Trial NCT05421546 gave 6mg/day spermidine for 15 weeks. Passed safety protocol. Test (N=20/20) of SPD as immune cell booster in aged after covid vaccination.

Vascarta commences a Phase I clinical study of VAS101 in osteoarthritis prn.to/4kQz8QT Trial of transdermal application of curcumin starts. Curcumin a known anti-inflammatory with limited bioavailability. May be an important development in arthritis treatment.

Dr. Greg Fahy: Thymus Regeneration & Boosting The Immune System For Long... youtu.be/Xj45rcfzrbM?si… via YouTube Excellent interview of DrFahy with MattK on thymus renewal and importance of immune sys in slowing aging. Very promising approach. @OptispanPodcast

Read this #preprint on Research Square: Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults. researchsquare.com/article/rs-568… Clinical trial NCT05421546 finding published (preprint) showing effectiveness of spermidine as

Prof Matt Kaeberlein: Beyond the Hallmarks: What are we missing in agein... youtu.be/hySlWn0f9m8?si… via YouTube Absolute great talk by Matt Kaeberlein on the status of aging research. Why in 50 years has nothing been found that beats calorie restriction in longevity

Improving the Long Term Immune Response to the Flu Vaccine (IRFLUVA) healthandcareresearchwales.org/researchers/ou… A follow-up study on the effectiveness of spermidine to vaccinations in the elderly is underway. This study looks at spermidine and flu vaccination efficiency. The PI is Dr Lucy

Thanks, open question about effectiveness of curcumin v quercetin. It would be great to test these biologics using the available inflammatory clocks.

ors.org/wp-content/upl… This is the finding from clinical trial NCT04210986 at the Steadman Clinic --fisetin as a potential treatment of knee osteoarthritis. Passed safety protocol but had no significant effect.

Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases pubmed.ncbi.nlm.nih.gov/39384074/ This is an excellent review of fisetin. Lists the multiple clinical trials involving fisetin. Bioavailability is a major issue including its pathway through the

Coffee vs Tea: One is Healthier than the Other youtu.be/e_idg7gmcQg?si… via YouTube A good review of the coffee v tea question. There are benefits to both and the analysis is difficult. Best guess: two cups of coffee in the morning and then some low caffeine tea in the

frontiersin.org/journals/immun… An important paper discussing the effect of spermidine treatment on osteoarthritis. From the Discussion Section: "SPD suppressed IL-1B -induced inflammation, attenuated ECM degradation, and upregulated matrix synthesis protection." This was a rodent

Hard to understand why with all the advances in computer power and studies of biomarkers and tens of thousands of papers published in the last thirty years there has been so little progress in the diagnostic tools used by primary physicians.

Medicine 3.0: Rethinking Prostate Cancer Screening youtu.be/hnamfo1AzWc?si… via YouTube This is the best free medical advice you will receive on PSA testing and prostrate cancer. Dr Peter Attia has done a wonderful public service giving this information.

Touch me It's so easy to leave me All alone with my memories of my days in the sun Look, a new day has begun

Perhaps we need to shift research from trying to find a plant based biological that improves health/lifespan to looking at mammalian based biologics. After all, plants evolve chemicals so that they can thrive. They may well help us but I think that is mainly an accident of

Caffeine Intake and Healthy Aging in Women #Nutrition2025 cdmcd.co/k9MRKx Another vote for coffee and caffeine consumption. Strength of study N = 47000, F , for 30 years. Observational. Tea or decaffeinated coffee did not show similar effect. Multiple other