Drug-induced hearing loss:

Irreversible:
-Aminoglycosides (Gentamycin and Amikacin)
-Chemotherapy (Cisplatin)
-Loop diuretics (Furosemide)

Reversible:
-Aspirin (high dose)
-PDE5i (Sildenafil and Tadalafil)
-Antimalarials (chloroquine and hydroxychloroquine)

The only approved indication for intravenous glutathione is ADJUNCT to reduce neurotoxicity following cisplatin chemotherapy.

Fatal reactions/events:
✅️Steven Johnsons Syndrome/TEN
✅️Thyroid problems
✅️Renal failure
✅️Infection/sepsis
✅️Hep B/HIV (needle sharing)

🔅Biliary Tract Cancers:
French National Clinical Practice Guideline

✅Localized disease: surgery and adjuvant capecitabine
✅No neoadjuvant treatment is validated to date
✅Advanced disease: Cisplatin-gemcitabine-durvalumab
✅Early biomarker testing
✅second line: FOLFOX…

T:👉 Metastatik Meme Kanserinde Beyin Metastazlarının Kontrolü İçin Bevacizumab, Etoposide ve Cisplatin (BEEP) İndüksiyon Tedavisi Tüm Beyin Radyoterapisi (WBRT) Öncesinde Ekstra Fayda Sağlar mı?

Bu soruya cevap arayan çalışmayı özetleyelim 👇

kanserpedia.com/metastatik-mem…

Antibody-drug conjugates by cisplatin, interesting mechanism of action 👀👀

Shows a Better response in cancer and sparing nearby cells

I have not worked with a black urologist & I will likely be the first for a lot of my patients. I yearn for diversity within urology. From my cancer survivor expected to becoming a urological oncologist. From cisplatin to surgeon #match2025 #urology #urosome #medtwitter

Cisplatin & Vincristine kicking cancer where it hurts 💪🧠♋️👊 proud is an understatement 💙 Together we will beat cancer 🙏

$ALLR Enormous potential for patented drug LiPlaCis.
If given FDA approval Allarity's AI drug formulation LiPlaCis could become the cancer chemo therapy of choice to compliment or rival the worlds most used chemo drug ...
cisplatin

🔎Intrahepatic cholangiocarcinoma (IHCC)

✅Neoadjuvant gemcitabin, cisplatin and nab-paclitaxel (NEO-GAP)
AnnalsSurgOncology

➡️A single arm, phase II trial
➡️30 patients, resectable but high-risk (tumor size > 5 cm, multiple tumors, presence of radiographic major vascular invasion,…

Cisplatin, Carboplatin: Nephro/Ototoxic
Cyclophosphamide, Ifosfmide: Hemorrhagic cystitis
Doxorubicin: Cardiotoxicity
Vinca: Peripheral neuropathy
TP1 (-): Diarrhea
Busulfan, Bleomycin: pulmonary fibrosis
Methotrexate, 5FU: Hepatotoxicity, Myelosuppression

Dr. Matthew Galsky's study unravels cisplatin's superiority in targeting cancer cells, boosting the immune system, and altering gene expression. These findings offer hope for improved treatments, marking a significant stride in the battle against metastatic bladder cancer.

📢Stage III to IVB nonkeratinizing nasopharyngeal carcinoma
JAMA Oncology

❓After 3x DCF induction, RT+ weekly cisplatin or only RT?

➡️The 3-year progression-free survival was 76.2% and 76.8%, P = .01 for noninferiority
➡️grade 3 to 4 short-term toxic effects was lower with RT…

An integrated view of cisplatin-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity: characteristics, c… link.springer.com/article/10.100…

Exciting news! 🎉 Thrilled to announce the publication of our article in European Journal of Surgical Oncology on nephroprotection in cisplatin-based HIPEC.
➡️ Preoperative hyperhydration proved useless. 💧🚫
➡️ No more renal failure with thiosulfate! 🙌
📚🔬RENAPE Network glen HCL - Hospices Civils de Lyon

➡️Local recurrence of endometrial cancer
☢️Planned definitive radiotherapy
💉Should concurrent weekly cisplatin be added ❓
NRG Oncology/GOG trial Journal of Clinical Oncology

❌Negative study
➡️Longer PFS with radiation mPFS: not reached for RT vs 73 months for chemoradiation, HR: 1.25 (95% CI,…

Nivo plus Gem cis got FDA approval for metastatic or advanced urothelial carcinoma. Median OS of 21.7 months.
Javelin 100 gave median OS of 31 months for cisplatin eligible pts ( With longer duration of follow up )

Only difference in two strategies is 6 additional cycles of…

Around One in Ten cancer patients cannot access cisplatin drugs for their Cancer chemotherapy.
BIDEN DO YOUR JOB!

⏩Our Iceberg Model in Imagining the New 1L Treatment Paradigm of mUC Matt Campbell MD, MS Omar Alhalabi, MD

The new EVP 'fissure' challenges the dichotomy of cisplatin/platinum fitness. What lurks beneath the surface?
👉Emerging #biomarkers & tx strategies: mdpi.com/2227-9059/12/3…

Cisplatin , fluorouracil , L-leucovorin and interferon alfa-2b for advanced head and neck cancer A pharmacologic analysis eurekamag.com/research/030/5…

Empowering Results for Urothelial Cancer Patients 📊
🔘First-line enfortumab vedotin (EV) treatments, either alone or with pembrolizumab, show positive impacts on the quality of life, functioning, and symptom relief in cisplatin-ineligible patients with locally…