Our communication on chemoenzymatic synthesis of substituted azepanes, combining application of imine reductases and organolithium chemistry by the labs of Jonathan Clayden and Turner Biocatalysis, was published in J. Am. Chem. Soc. :
pubs.acs.org/doi/abs/10.102…
Our recent work on Streamlined Chemoenzymatic Synthesis of Cyclic Peptides by Non-ribosomal Peptide Cyclases is out in J. Am. Chem. Soc. . Congrats for Masa and Kei! pubs.acs.org/doi/10.1021/ja…
Interesting review about chemical reporter strategies to study mammalian O-glycosylation: oxidation of cell surface glycans, metabolic oligosaccharide engineering, chemoenzymatic glycan labelling, bump-and-hole strategies bit.ly/3xcnRS7
#glycotime
We are looking for a postdoc (up to 3 years!) in chemoenzymatic oligosaccharide synthesis in a Wellcome-funded Biomedical Resource Grant with the Glycosciences Lab Glycosciences Lab Prof. Ten Feizi! #glycotime imperial.ac.uk/jobs/descripti… 1/4
Congrats to the non-heme team on their JACS paper demonstrating a chemoenzymatic synthetic strategy for making ortho-quinone methides Tyler Doyon Jonathan Perkins Summer Evan Romero @kevincsumich Zimmerman Group #biocatalysis Michigan Chemistry
pubs.acs.org/doi/10.1021/ja…
Recombinant human erythropoietin (EPO) and its 3 N-glycans: a robust and reproducible chemoenzymatic approach to glycoforms of EPO with and without sialic acids. Biological activity confirmed. Angewandte Chemie bit.ly/3lMdCia
#glycotime
Today, we had insightful discussions with laureate John F. Hartwig The Hartwig Group UC Berkeley who received the 2022 Emanuel-Merck-Lectureship. During his impressive talk yesterday, he walked us through the efforts of chemoenzymatic #catalysis . Thank you John for being with us!
KFB Lab Paper Alert!: Our recent review that highlights recent examples of cooperative chemoenzymatic processes is now available as an accepted article ChemBioChem!
…mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…
New from my lab in ACS Catalysis! Using our knowledge of enzyme superfamilies to predict a new & practical heterocycle synthesis. #biocatalysis #MyFirstACSCatal
Repurposing an Aldolase for the Chemoenzymatic Synthesis of Substituted Quinolines pubs.acs.org/doi/10.1021/ac…
#Enzyme Library-enabled #Chemoenzymatic Tropolone Synthesis by Jonathan Perkins, Alexandra Golliher, José Hernández-Meléndez, Anthony Saucedo, Tyler Doyon, Alison Narayan Narayan Lab @ UMich at Michigan Chemistry UMLifeSciences in ChemRxiv chemrxiv.org/engage/chemrxi…
An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Synthesis Catalysis by Paul S. Riehl at Science At BMS, Jesmine Lim, James D. Finnigan, Simon J. Charnock at Prozomix, and Todd K. Hyster Hyster Lab at CornellChemistry in Organic Process Research & Development pubs.acs.org/doi/10.1021/ac…
Our new paper on chemoenzymatic synthesis of hydroxysulfide with KREDs is now available in Angewandte Chemie! Well done Fei Zhao #BioPhoCS MarieSkłodowskaCurie and Prozomix for great enzymes! UCL Chemistry School of Cancer & Pharmaceutical Sciences #biocatalysis #chemicalsustainability onlinelibrary.wiley.com/doi/10.1002/an…