$EL is so desperate for a rally in its stock; headlines like these boost the stock ...for a day:

' $EL will host a “Sirtuins and Longevity” symposium on July 6 that will feature “key research” on the relationship between sirtuins and their impact on skin.'

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Roles of sirtuin family members in chronic obstructive pulmonary disease
respiratory-research.biomedcentral.com/articles/10.11…
Sirtuins play an important role in metabolic diseases, cell cycle control, proliferation, apoptosis, and senescence. Owing to differences in subcellular localization, sirtuins
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Charles Brenner, PhD Scientific dissent is important. It will inevitably lead more research and an answer questions about sirtuins and their role in human health (if any).

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3) The potential health benefits of TRF may be due to its effects on pathways like mTOR, AMPK, Sirtuins, and insulin/IGF1 signaling, which regulate nutrient intake, processing, and gene expression in the body.

unherd.com/2023/06/idewha…

interleukin-8 measured in sputum from COPD patients. Further, it is hypothesized that augmentation of NAD+ in COPD patients might alleviate symptoms through activation of sirtuins.
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here's Derek Lowe summary of the paper in his Science Magazine blog

science.org/content/blog-p…

Jain Fasting & Sirtuin: 'During the 1st quarter of the year, very deep, speedy, & broad research is in progress on a family of 7 sirtuins, that are promising enzymes in the treatment of critical & chronic neurological, cardiovascular, & carcinogenic maladies. These secretions ...

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Tony Huge What's your take on the study of Sirtuins, is it just another balloon that is being created to sell supplements or is it legit.
Does NMN & NAD + really work....

Therefore, it is important to identify the complex pathways involved in the pathogenesis of COPD. Sirtuins, as important anti-aging molecules, are involved in regulating oxidative stress and chronic inflammatory response, and may be involved in the occurrence and development
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twitter.com/TimothyDSnyder…

2/2. News cycle is a little behind Russian events. Following Jimmy Rushton Dmitri @juliadavisnews Yaroslav Trofimov can help. Oh and Christo Grozev has been predicting something like this for a year.

Naman Hebbar TheLiverDoc But sirtuins are said to be genes in the video?

Allie David Sinclair i think ppl are ready for the truth

this is really important bc if they were dominant longevity genes, we'd want to CRISPR them in

but they're not

doi.org/10.1093/lifeme…

of COPD; these activators may be potential therapeutic targets. From this perspective, sirtuins appear to be important target molecules and will be further discussed in this review.
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exhibit anisotropy. In this narrative review, we discuss the roles and molecular pathways of each member of the sirtuin family involved in COPD to provide novel insights into the prevention and treatment of COPD and how sirtuins may serve as adjuvants for COPD treatment.
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Alan Aragon Charles Brenner, PhD Bhupinder Thakur I need to reread lifespan. I certainly recall sirtuins being discussed, but not as the focal point of the book. In a perfect world, you could cite to someone other than yourself for some of the key statements in the review. Your objectivity is questionable in this matter.

Btw, here’s Dudley Lamming Lab, a hero who, as a student, showed in Science Magazine that multiple yeast sirtuins are required for calorie restriction to extend lifespan in yeast & are redundant, so deleting one gene doesn’t have a huge effect. Published in 2005, at a time of…

In recent years, the sirtuin family has been extensively studied, leading to some remarkable discoveries. However, there have been very few studies on the impact of sirtuins on COPD. Therefore, it is important to further explore sirtuins as potential therapeutic targets of the...

disease. Specific drugs such as sirtuin-related agonists may prove to be an effective treatment strategy for COPD. However, owing to the abundant effects of sirtuins, such targeting may lead to potential side effects. Therefore, further studies are required to verify the roles
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there are 127 references in this piece

academic.oup.com/lifemeta/artic…